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1. (WO1997019178) AUTOANTIGENIC METAL PROTEASES AND METHODS OF DIAGNOSING AUTOIMMUNE DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019178 International Application No.: PCT/DE1996/002094
Publication Date: 29.05.1997 International Filing Date: 04.11.1996
Chapter 2 Demand Filed: 15.05.1997
IPC:
C07K 14/47 (2006.01) ,C12N 9/50 (2006.01) ,G01N 33/564 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
564
for pre-existing immune complex or autoimmune disease
Applicants:
UNIVERSITÄT KONSTANZ [DE/DE]; Universitätsstrasse 10 D-78434 Konstanz, DE (AllExceptUS)
KRAWINKEL, Ulrich [DE/DE]; DE (UsOnly)
MAUCH, Simon [DE/DE]; DE (UsOnly)
SEDLACEK, Radislav [DE/DE]; DE (UsOnly)
Inventors:
KRAWINKEL, Ulrich; DE
MAUCH, Simon; DE
SEDLACEK, Radislav; DE
Agent:
PERREY, Ralf; Müller-Boré & Partner Grafinger Strasse 2 D-81671 München, DE
Priority Data:
195 43 265.720.11.1995DE
Title (DE) AUTOANTIGENE METALLPROTEASEN UND VERFAHREN ZUR DIAGNOSE VON AUTOIMMUNKRANKHEITEN
(EN) AUTOANTIGENIC METAL PROTEASES AND METHODS OF DIAGNOSING AUTOIMMUNE DISEASES
(FR) PROTEASES METALLIQUES AUTOANTIGENES ET PROCEDES PERMETTANT DE DIAGNOSTIQUER DES MALADIES AUTO-IMMUNES
Abstract:
(DE) Die vorliegende Erfindung betrifft Nukleinsäuren, die mindestens eine für ein Polypeptid kodierende Nukleinsäuresequenz enthalten, wobei das Polypeptid mindestens eine aus einer Metallprotease stammende autoantigene Determinante enthält, das Polypeptid selbst sowie gegen das Polypeptid gerichtete Antikörper und gegen das Polypeptid gerichtete spezifische Inhibitoren. Ferner betrifft die vorliegende Erfindung Verfahren und Kits zum Nachweis von autoantigenen Metallproteasen und von Autoimmunkrankheiten wie rheumatoide Arthritis.
(EN) The invention concerns nucleic acids which contain at least one nucleic acid sequence coding for a polypeptide, the polypeptide containing at least one autoantigenic determinant originating from a metallic protease. The invention also concerns the polypeptide itself, antibodies directed at the polypeptide and specific inhibitors directed at the polypeptide. The invention further concerns methods and kits for detecting autoantigenic metallic proteases and autoimmune diseases, such as rheumatoid arthritis.
(FR) L'invention concerne des acides nucléiques, qui contiennent au moins une séquence d'acide nucléique codant un polypeptide. Le polypeptide contient au moins un déterminant autoantigénique issu d'une protéase métallique. L'invention concerne également ledit polypeptide, des anticorps dirigés contre le polypeptide et des inhibiteurs spécifiques dirigés contre le polypeptide. L'invention concerne en outre des procédés et des nécessaires permettant de détecter la présence de protéases métalliques autoantigéniques et de maladies auto-immunes telles que l'arthrite rhumatoïde.
Designated States: CA, GB, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
AU1997017176