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1. (WO1997019176) MALATHION CARBOXYLESTERASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019176 International Application No.: PCT/AU1996/000746
Publication Date: 29.05.1997 International Filing Date: 22.11.1996
Chapter 2 Demand Filed: 27.05.1997
IPC:
A62D 3/00 (2007.01) ,C02F 1/58 (2006.01) ,C12N 9/18 (2006.01)
A HUMAN NECESSITIES
62
LIFE-SAVING; FIRE-FIGHTING
D
CHEMICAL MEANS FOR EXTINGUISHING FIRES; PROCESSES FOR MAKING HARMFUL CHEMICAL SUBSTANCES HARMLESS, OR LESS HARMFUL, BY EFFECTING A CHEMICAL CHANGE; COMPOSITION OF MATERIALS FOR COVERINGS OR CLOTHING FOR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; COMPOSITION OF MATERIALS FOR TRANSPARENT PARTS OF GAS-MASKS, RESPIRATORS, BREATHING BAGS OR HELMETS; COMPOSITION OF CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
3
Processes for making harmful chemical substances harmless, or less harmful, by effecting a chemical change in the substances
C CHEMISTRY; METALLURGY
02
TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
F
TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
1
Treatment of water, waste water, or sewage
58
by removing specified dissolved compounds
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
18
Carboxylic ester hydrolases
Applicants:
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION [AU/AU]; Limestone Avenue Campbell, ACT 2601, AU (AllExceptUS)
RUSSELL, Robyn, Joyce [AU/AU]; AU (UsOnly)
NEWCOMB, Richard, David [NZ/NZ]; NZ (UsOnly)
CAMPBELL, Peter, Malcolm [AU/AU]; AU (UsOnly)
ROBIN, Geoffrey, Charles de Quetteville [AU/AU]; AU (UsOnly)
CLAUDIANOS, Charles [AU/AU]; AU (UsOnly)
SMYTH, Kerrie-Ann [AU/US]; US (UsOnly)
BOYCE, Thomas, Mark [US/US]; US (UsOnly)
OAKESHOTT, John, Graham [AU/AU]; AU (UsOnly)
BROWNLIE, Jeremy, Colin [AU/AU]; AU (UsOnly)
Inventors:
RUSSELL, Robyn, Joyce; AU
NEWCOMB, Richard, David; NZ
CAMPBELL, Peter, Malcolm; AU
ROBIN, Geoffrey, Charles de Quetteville; AU
CLAUDIANOS, Charles; AU
SMYTH, Kerrie-Ann; US
BOYCE, Thomas, Mark; US
OAKESHOTT, John, Graham; AU
BROWNLIE, Jeremy, Colin; AU
Agent:
F.B. RICE & CO.; 28A Montague Street Balmain, NSW 2041, AU
Priority Data:
PN 675123.11.1995AU
Title (EN) MALATHION CARBOXYLESTERASE
(FR) CARBOXYLESTERASE AGISSANT SUR LE MALATHION
Abstract:
(EN) The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethyloxon organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60 %, preferably at least 80 % and more preferably at least 95 % homology with Lc$g(a)E7, in which the protein encoded by the DNA molecule differs from E3 at least in the substitution of Trip at position 251 with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.
(FR) La présente invention concerne une molécule d'ADN isolée codant la carboxylestérase agissant sur le malathion et capable d'hydrolyser l'un au moins des organophosphates appartenant au groupe des carboxylester organophosphates et dyméthyloxone organophosphates. La molécule d'ADN comprend une séquence nucléotide présentant une homologie au moins à 60 %, de préférence au moins à 80 % et encore mieux au moins à 95 % avec Lc$g(a)E7, séquence dans laquelle la protéine codée par la molécule d'ADN diffère de E3 au moins dans la substitution du Trip en position 251 par un acide aminé choisi dans le groupe des Leu, Ser, Ala, Ile, Val, Thr, Cys, Met et Gly, les substituants préférés étant Leu et Ser.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1998/004053IL119675EP0862636US6235515US20030143711JP4112617
AR04751CA2236793DE000069636811PT862636NZ321919AU1996075572
MYPI 96004909