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1. (WO1997019169) TUMOUR VACCINE AND PROCESS FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019169 International Application No.: PCT/EP1996/005126
Publication Date: 29.05.1997 International Filing Date: 21.11.1996
Chapter 2 Demand Filed: 17.06.1997
IPC:
A61K 39/00 (2006.01) ,A61K 39/145 (2006.01) ,A61K 39/39 (2006.01) ,C07K 7/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
Applicants:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Postfach 200 D-55216 Ingelheim am Rhein, DE (AllExceptUS)
SCHMIDT, Walter [DE/AT]; AT (UsOnly)
BIRNSTIEL, Max [CH/AT]; AT (UsOnly)
SCHWEIGHOFFER, Tamàs [HU/AT]; AT (UsOnly)
STEINLEIN, Peter [DE/AT]; AT (UsOnly)
BUSCHLE, Michael [DE/AT]; AT (UsOnly)
Inventors:
SCHMIDT, Walter; AT
BIRNSTIEL, Max; AT
SCHWEIGHOFFER, Tamàs; AT
STEINLEIN, Peter; AT
BUSCHLE, Michael; AT
Common
Representative:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Postfach 200 D-55216 Ingelheim am Rhein, DE
Priority Data:
195 43 649.023.11.1995DE
196 07 044.924.02.1996DE
Title (DE) TUMORVAKZINE UND VERFAHREN ZU IHRER HERSTELLUNG
(EN) TUMOUR VACCINE AND PROCESS FOR THE PREPARATION THEREOF
(FR) VACCIN TUMORAL ET SON PROCEDE DE FABRICATION
Abstract:
(DE) Tumorvakzine und Verfahren zu deren Herstellung. Die Tumorvakzine enthält Tumorzellen, von denen zumindest ein Teil mindestens einen MHC-I-Haplotyp des Patienten an der Zelloberfläche aufweist, und die mit einem oder mehreren Peptiden, die an das MHC-I-Molekül binden, derart beladen wurden, daß die Tumorzellen im Kontext mit den Peptiden vom Immunsystem des Patienten als fremd erkannt werden und eine zelluläre Immunantwort auslösen. Die Beladung wird in Gegenwart eines Polykations wie Polylysin vorgenommen.
(EN) The invention relates to a tumour vaccine and a process for the preparation thereof. The tumour vaccine contains tumour cells, at least a portion of which has at least one MHC-I-haplotype of the patient on the cell surface, and which have been loaded in such a manner with one or a plurality of peptides bonding to the MHC-I-molecule that said tumour cells are recognised as foreign within the context of the peptides by the patient's immune system and trigger a cellular immune response. Loading takes place in the presence of a polycation such as polylysine.
(FR) L'invention se rapporte à un vaccin tumoral et à son procédé de fabrication. Le vaccin tumoral contient des cellules tumorales dont au moins une partie présente au moins un haplotype MHC-I du patient à la surface de la cellule et qui ont été chargées avec un ou plusieurs peptides se liant à la molécule MHC-I, de telle façon que les cellules tumorales, dans le contexte des peptides, sont reconnues comme étrangères par le système immunitaire du patient et déclenchent une réponse immunitaire cellulaire. La charge s'effectue en présence d'un polycation tel que la polylysine.
Designated States: AU, BG, BR, BY, CA, CN, CZ, EE, HU, IL, JP, KR, KZ, LT, LV, MX, NZ, PL, RO, RU, SG, SK, TR, UA, US, UZ, VN
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
CZPV1998-1589SK66998TR1998/00912MXPA/a/1998/003930SG53728VN3226
EP0866851RU02206329US20020085997JP2000502052CN1202931CA2238176
KR1019990067653NZ322910AU1996076947VN3226