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1. (WO1997019112) INHIBITORY AND NON-INHIBITORY ANTIGEN BINDING POLYPEPTIDES AGAINST HUMAN P450 ENZYMES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019112 International Application No.: PCT/US1996/017781
Publication Date: 29.05.1997 International Filing Date: 15.11.1996
Chapter 2 Demand Filed: 09.06.1997
IPC:
C07K 16/40 (2006.01) ,C12N 9/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
Applicants:
UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer Suite 325, 6011 Executive Boulevard Rockville, MD 20852-3804, US
Inventors:
GELBOIN, Harry, V.; US
GONZALEZ, Frank, J.; US
Agent:
LIEBESCHUETZ, Joe ; Townsend and Townsend and Crew L.L.P. Two Embarcadero Center, 8th Floor, San Francisco, CA 94111-3834, US
Priority Data:
08/559,80817.11.1995US
Title (EN) INHIBITORY AND NON-INHIBITORY ANTIGEN BINDING POLYPEPTIDES AGAINST HUMAN P450 ENZYMES
(FR) POLYPEPTIDES DE LIAISON D'ANTIGENES INHIBITEURS ET NON INHIBITEURS CONTRE DES ENZYMES HUMAINES P450
Abstract:
(EN) Antigen binding polypeptides that specifically bind human cytochrome P450 3A3, 3A4, and 3A5 and that specifically inhibit the enzyme activity of human cytochrome P450 3A3, 3A4, and 3A5 are described. Antigen binding polypeptides that specifically bind to human cytochrome P450 3A3 and 3A4 are also described. Antigen binding polypeptides which specifically bind to human cytochrome P450 2E1 and which specifically inhibit the enzyme activity of human cytochrome P450 2E1 are described. Antigen binding polypeptides which specifically bind to human cytochrome P450 2E1 are also described. Methods of determining the contribution of human cytochrome P450s to the metabolism of compounds, using the antigen binding polypeptides of the invention, are also described.
(FR) L'invention décrit divers polypeptides de liaison d'antigènes et notamment des polypeptides liant spécifiquement les cytochromes humains P450 3A3, 3A4 et 3A5 et inhibant spécifiquement l'activité enzymatique des cytochromes précités; des polypeptides de liaison d'antigènes se liant spécifiquement aux cytochromes humains P450 3A3 et 3A4; des polypeptides de liaison d'antigènes se liant spécifiquement au cytochrome humain P450 2E1 et inhibant spécifiquement l'activité enzymatique de ce dernier; des polypeptides de liaison d'antigènes se liant spécifiquement au cytochrome humain P450 2E1; elle porte en outre sur des procédés de détermination de la contribution des cytochromes humains P450 au métabolisme de composés à l'aide des polypeptides de liaison d'antigènes.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0861268CA2238014CA2629643AU1996076701