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1. (WO1997019107) IDENTIFICATION OF ANTIGENES FROM POST-INFECTION NEMATODES FOR THE PURPOSE OF DEVELOPING NEW ANTHELMINTICS AND VACCINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019107 International Application No.: PCT/EP1996/004918
Publication Date: 29.05.1997 International Filing Date: 11.11.1996
Chapter 2 Demand Filed: 19.03.1997
IPC:
A61K 39/00 (2006.01) ,C07K 14/435 (2006.01) ,C12N 9/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
12
transferring phosphorus containing groups, e.g. kinases (2.7)
Applicants:
BAYER AKTIENGESELLSCHAFT [DE/DE]; D-51368 Leverkusen, DE (AllExceptUS)
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., BERLIN [DE/DE]; Hofgartenstrasse 2 D-80539 München, DE (AllExceptUS)
HARDER, Achim [DE/DE]; DE (UsOnly)
LONDERSHAUSEN, Michael [DE/DE]; DE (UsOnly)
EISENBEISS, Wilhelm, Friedrich [DE/DE]; DE (UsOnly)
Inventors:
HARDER, Achim; DE
LONDERSHAUSEN, Michael; DE
EISENBEISS, Wilhelm, Friedrich; DE
Common
Representative:
BAYER AKTIENGESELLSCHAFT; D-51368 Leverkusen, DE
Priority Data:
195 43 554.022.11.1995DE
Title (DE) IDENTIFIZIERUNG VON ANTIGENEN AUS POST-INFEKTIÖSEN NEMATODEN ZUR ENTWICKLUNG NEUER ANTHELMINTIKA UND VAKZINEN
(EN) IDENTIFICATION OF ANTIGENES FROM POST-INFECTION NEMATODES FOR THE PURPOSE OF DEVELOPING NEW ANTHELMINTICS AND VACCINES
(FR) IDENTIFICATION D'ANTIGENES A PARTIR DE NEMATODES POST-INFECTIEUX POUR LE DEVELOPPEMENT DE NOUVEAUX ANTHELMINTIQUES ET VACCINS
Abstract:
(DE) Die Erfindung betrifft isolierte Antigene aus Nematoden in einer im wesentlichen reinen Form, die immunologisch mit einem protektiven Antiserum reagieren, das gegen Nematodenlarven im Stadium der Häutung von L3 zu L4 gerichtet ist, wobei die Antigene durch in vitro-Kultivierung von Nematodenlarven im L4-Stadium und Gewinnung aus dem Kulturüberstand erhältlich sind. Weiterhin wird ein Verfahren zur Gewinnung dieser Antigene und deren Verwendung zur Entwicklung neuer Anthelmintika und Vakzinen beschrieben.
(EN) The invention concerns antigenes isolated from nematodes in essentially pure form and which show an immunological reaction with a protective anti-serum used against nematode larvae at the skin-shedding stage from L3 to L4, the antigenes being obtained by the $i(in vitro) cultivation of nematode larvae in the L4 stage and extraction from the surplus culture. The invention also concerns a method of obtaining such antigenes and their use in the development of new anthelmintics and vaccines.
(FR) L'invention concerne des antigènes isolés à partir de nématodes sous une forme essentiellement pure. Ces antigènes réagissent immunologiquement avec un antisérum protecteur, lequel est dirigé contre les larves de nématodes au stade de la mue de L3 à L4. Les antigènes sont obtenus par culture in vitro de larves de nématodes au stade L4 et par extraction à partir de l'excès de culture. L'invention concerne également un procédé de production de ces antigènes et leur utilisation pour développer de nouveaux anthelmintiques et vaccins.
Designated States: AU, BB, BG, BR, BY, CA, CN, CZ, HU, IL, JP, KR, KZ, LK, MX, NO, NZ, PL, RO, RU, SK, TR, UA, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
EP0868433JP2000500474AU1996075693