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1. (WO1997019091) NOVEL GERANYLGERANYL-DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND RELATED PHARMACEUTICAL COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019091 International Application No.: PCT/EP1996/005202
Publication Date: 29.05.1997 International Filing Date: 21.11.1996
Chapter 2 Demand Filed: 12.06.1997
IPC:
C07C 307/04 (2006.01) ,C07C 307/06 (2006.01) ,C07F 9/38 (2006.01) ,C07F 9/40 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
307
Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
04
Diamides of sulfuric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
307
Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
04
Diamides of sulfuric acids
06
having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
40
Esters thereof
Applicants:
LABORATORI BALDACCI S.P.A. [IT/IT]; Via San Michele degli Scalzi, 73 I-56100 Pisa, IT (AllExceptUS)
BALSAMO, Aldo [IT/IT]; IT (UsOnly)
MACCHIA, Bruno [IT/IT]; IT (UsOnly)
MACCHIA, Marco [IT/IT]; IT (UsOnly)
BALDACCI, Massimo [IT/IT]; IT (UsOnly)
DANESI, Romano [IT/IT]; IT (UsOnly)
DEL TACCA, Mario [IT/IT]; IT (UsOnly)
Inventors:
BALSAMO, Aldo; IT
MACCHIA, Bruno; IT
MACCHIA, Marco; IT
BALDACCI, Massimo; IT
DANESI, Romano; IT
DEL TACCA, Mario; IT
Agent:
DRAGOTTI, Gianfranco; Saic Brevetti S.r.l. Galleria San Babila, 4/D I-20122 Milano , IT
Priority Data:
MI95A00243123.11.1995IT
Title (EN) NOVEL GERANYLGERANYL-DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND RELATED PHARMACEUTICAL COMPOSITIONS
(FR) NOUVEAUX DERIVES GERANYL-GERANYLE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
Abstract:
(EN) The present invention relates to novel geranylgeranyl-derivatives and the pharmaceutically acceptable salts thereof having antiproliferative acitivity in eukaryotic cells with respect to the inhibition of protein geranylgeranylation. The invention also relates to the pharmaceutical compositions containing the novel derivatives and to the process for the preparation thereof.
(FR) L'invention concerne des dérivés géranyl-géranyle et leurs sels acceptables sur le plan pharmaceutique. Ces dérivés ont une activité antiproliférative vis-à-vis des cellules eukaryotes, l'inhibition intervenant par la géranyl-géranylation de protéines. L'invention concerne également des compositions pharmaceutiques contenant le nouveau dérivé et le procédé de préparation de celui-ci.
Designated States: AM, AU, BB, BG, BR, BY, CA, CN, CZ, EE, GE, HU, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LV, MD, MG, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SI, SK, TJ, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862575US6242433JP2000500758 CA2238389AU1997010316