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1. (WO1997019085) CAMPTOTHECIN COMPOUNDS WITH COMBINED TOPOISOMERASE I INHIBITION AND DNA ALKYLATION PROPERTIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019085 International Application No.: PCT/US1996/018282
Publication Date: 29.05.1997 International Filing Date: 22.11.1996
Chapter 2 Demand Filed: 23.06.1997
IPC:
C07D 491/22 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
22
in which the condensed system contains four or more hetero rings
Applicants:
RESEARCH TRIANGLE INSTITUTE [US/US]; 3040 Cornwallis Road P.O. Box 12194 Research Triangle Park, NC 27709, US
Inventors:
WALL, Monroe, E.; US
WANI, Mansukh, C.; US
Agent:
SCHWARTZ, Timothy, R.; Oblon, Spivak, McClelland, Maier & Neustadt, P.C. Crystal Square Five 4th floor 1755 Jefferson Davis Highway Arlington, VA 22202, US
Priority Data:
08/561,66422.11.1995US
Title (EN) CAMPTOTHECIN COMPOUNDS WITH COMBINED TOPOISOMERASE I INHIBITION AND DNA ALKYLATION PROPERTIES
(FR) COMPOSES DE CAMPTOTHECINE A PROPRIETES COMBINEES D'INHIBITION DE LA TOPOISOMERASE I ET D'ALKYLATION DE L'ADN
Abstract:
(EN) Camptothecin compounds having a -CH2-L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and alkylate DNA of associated topoisomerase I-DNA complexes.
(FR) Les composés de camptothécine possédant un groupe -CH2-L sont des anti-tumoraux efficaces. Ils inhibent l'enzyme topoisomérase I et alkylent l'ADN des complexes de topoisomérase I-ADN associés.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996077329