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1. (WO1997019068) SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019068 International Application No.: PCT/US1996/016761
Publication Date: 29.05.1997 International Filing Date: 18.10.1996
Chapter 2 Demand Filed: 04.06.1997
IPC:
C07D 211/10 (2006.01) ,C07D 295/096 (2006.01) ,C07D 401/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
08
with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
10
with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04
with substituted hydrocarbon radicals attached to ring nitrogen atoms
08
substituted by singly bound oxygen or sulfur atoms
096
with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
WARNER-LAMBERT COMPANY [US/US]; 201 Tabor Road Morris Plains, NJ 07950, US (AllExceptUS)
ORTWINE, Daniel, Fred [US/US]; US (UsOnly)
PURCHASE, Claude, Forsey, Jr. [US/US]; US (UsOnly)
WHITE, Andrew, David [GB/US]; US (UsOnly)
Inventors:
ORTWINE, Daniel, Fred; US
PURCHASE, Claude, Forsey, Jr.; US
WHITE, Andrew, David; US
Agent:
RYAN, M., Andrea; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 , US
TESCH, R. ; Warner-Lambert Company Legal Division c/o Gödecke AG, Patents Mooswaldallee 1 F-79090 Freiburg, DE
Priority Data:
60/007,37217.11.1995US
Title (EN) SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES
(FR) INHIBITEURS DE METALLOPROTINEASES MATRICIELLES A BASE DE SULFAMIDE
Abstract:
(EN) Sulfonamide compounds are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes using the compounds.
(FR) L'invention a trait à des composés de sulfamide, inhibiteurs de métalloprotinéases matricielles, notamment la stromélysine-1 et la gélatinase A (gélatinase de 72 kD). Elle concerne également des méthodes faisant appel à ces composés pour le traitement de la sclérose en plaques, de la rupture de la plaque athéroscléreuse, de l'anévrisme aortique, de l'insuffisance cardiaque, de la resténose, de la parodontopathie, de l'ulcération cornéenne, des brûlures, des ulcères du décubitus, d'ulcères chroniques ou de lésions, de métastases cancéreuses, de l'angiogénèse tumorale, de l'arthrite ou d'autres affections auto-immunes ou inflammatoires liées à une invasion leucocytaire des tissus.
Designated States: AL, AU, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KE, KR, LK, LR, LS, LT, LV, MG, MK, MN, MW, MX, NO, NZ, PL, RO, SD, SG, SI, SK, TR, TT, UA, UG, US, UZ, VN
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1998-1467NO19982223SK64198IL123901EP0874836US5977141
JP2000514779 CA2233560NZ321293AU1996074641