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1. (WO1997019058) 25-HYDROXY-16-ENE-26,27-BISHOMO-CHOLECALCIFEROLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019058 International Application No.: PCT/EP1996/004954
Publication Date: 29.05.1997 International Filing Date: 13.11.1996
Chapter 2 Demand Filed: 24.05.1997
IPC:
C07C 35/32 (2006.01) ,C07C 45/29 (2006.01) ,C07C 45/30 (2006.01) ,C07C 49/513 (2006.01) ,C07C 401/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
35
Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
22
polycyclic, at least one hydroxy group bound to a condensed ring system
23
with a hydroxy group on a condensed ring system having two rings
32
the condensed ring system being a [4.3.0] system, e.g. indenols
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
27
by oxidation
29
of hydroxy groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
27
by oxidation
30
with halogen containing compounds, e.g. hypohalogenation
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
385
Saturated compounds containing a keto group being part of a ring
487
containing hydroxy groups
507
polycyclic
513
a keto group being part of a condensed ring system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
401
Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basle, CH
Inventors:
IACOBELLI, Jerome, Anthony; US
USKOKOVIC, Milan, Radoje; US
Agent:
MAHE, Jean; Grenzacherstrasse 124 CH-4070 Basle, CH
Priority Data:
60/008,74422.11.1995US
Title (EN) 25-HYDROXY-16-ENE-26,27-BISHOMO-CHOLECALCIFEROLS
(FR) 25-HYDROXY-16-ENE-26,27-BISHOMO-CHOLECALCIFEROLS
Abstract:
(EN) The invention relates to a compound of formula (I) wherein A is a carbon-carbon double bond having the E or Z stereochemical configuration, or A is a carbon-carbon triple bond, Et is ethyl, and R is hydroxy and R1 is hydrogen or =CH2, or R is hydrogen or fluoro and R1 is =CH2. They stimulate HL-60 cell differentiation and accordingly, are useful as agents for the treatment of neoplastic diseases, such as leukemia.
(FR) L'invention concerne un composé de la formule (I) dans laquelle A représente une liaison double carbone-carbone possédant la configuration stéréochimique E ou Z, ou bien A représente une liaison triple carbone-carbone, E représente éthyle, R représente hydroxy et R1 représente hydrogène ou =CH2, ou bien R représente hydrogène ou fluoro et R1 représente =CH2. Ces composés stimulent la différenciation des cellules HL-60 et ils sont utiles en tant qu'agents de traitement de maladies néoplasiques, telles que la leucémie.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KP, KR, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1998-1572NO19982304TR1998/00908SG53650IL124290EP0874814
JP2007126458JP2000500476 AR04726CN1202885CA2237897EA199800468
KR1019990071535NZ322035AU1996075702DK0874814MYPI 96004829