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1. (WO1997019048) SYNTHESIS OF PROPIONIC ACID DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019048 International Application No.: PCT/GB1996/002708
Publication Date: 29.05.1997 International Filing Date: 05.11.1996
Chapter 2 Demand Filed: 02.06.1997
IPC:
C07C 69/734 (2006.01) ,C12P 41/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
66
Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73
of unsaturated acids
734
Ethers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41
Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
Applicants:
AECI LIMITED [ZA/ZA]; Carlton Centre Office Tower 16the floor Commissioner Street Johannesburg 2001, ZA (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GN, GR, HU, IE, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN)
DYER, Alison, Margaret [GB/ZA]; ZA (IS)
Inventors:
DYER, Alison, Margaret; ZA
MARAIS, Stephanus, Francois; ZA
KHAILE, Thebeeapelo, John; ZA
NJAMELA, Owen, Lungile; ZA
BRAITHWAITE, Dana, Helen; ZA
DAVIDSON, Deborah, Nicole; ZA
JUNGMANN, Christa, Maria; ZA
PARKINSON, Christopher, John; ZA
GARDINER, Neil, Stockenstrom; ZA
STEENKAMP, Lucia, Hendrina; ZA
SKEIN, Etienne, Van Eeden; ZA
Agent:
W.P. THOMPSON & CO.; Coopers Building Church Street Liverpool L1 3AB, GB
Priority Data:
95/979217.11.1995ZA
96/342030.04.1996ZA
Title (EN) SYNTHESIS OF PROPIONIC ACID DERIVATIVES
(FR) SYNTHESE DE DERIVES DE L'ACIDE PROPIONIQUE
Abstract:
(EN) A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of $g(a)-arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.
(FR) L'invention concerne un procédé pour la production de dérivés de l'acide propionique disubstitués, qui sont des intermédiaires dans la synthèse des acides $g(a)-arylpropioniques tels que le naproxène. Ce procédé consiste à faire réagir un dérivé de la naphthalène tel que le 2-méthoxynaphthalène avec un agent d'alkylation tel qu'un pyruvate d'alkyle en présence d'un catalyseur, et ensuite à assurer sa déshydratation et son hydrogénolyse ou directement son hydrogénolyse, ou à former son dérivé et ensuite à hydrogénolyser son produit, pour produire le composé requis.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996073246