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1. (WO1997019039) SOLID PHASE SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND COMBINATORIAL COMPOUND LIBRARY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019039 International Application No.: PCT/EP1996/004808
Publication Date: 29.05.1997 International Filing Date: 05.11.1996
Chapter 2 Demand Filed: 05.05.1997
IPC:
C07B 61/00 (2006.01) ,C07D 231/12 (2006.01) ,C07D 261/08 (2006.01) ,C07D 403/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61
Other general methods
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
12
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
261
Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
02
not condensed with other rings
06
having two or more double bonds between ring members or between ring members and non-ring members
08
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
NOVARTIS AG [CH/CH]; Schwarzwaldallee 215 CH-4058 Basel, CH (AllExceptUS)
MARZINZIK, Andreas [DE/DE]; DE (UsOnly)
FELDER, Eduard [CH/CH]; CH (UsOnly)
Inventors:
MARZINZIK, Andreas; DE
FELDER, Eduard; CH
Common
Representative:
NOVARTIS AG; Patentabteilung Klybeckstrasse 141 D-4002 Basle, CH
Priority Data:
95810717.917.11.1995EP
Title (EN) SOLID PHASE SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND COMBINATORIAL COMPOUND LIBRARY
(FR) SYNTHESE EN PHASE SOLIDE DE COMPOSES HETEROCYCLIQUES ET D'UNE BANQUE COMBINATOIRE DE COMPOSES
Abstract:
(EN) Here we report a study on a reaction sequence on solid phase, suitable for the generation of molecular diversity on small heterocycles of the pyrazole and isoxazole type. For each reaction, suitable conditions on solid phase were worked out and a variety of reactive agents (building blocks) was utilized in an effort to grasp the system's breadth of applicability. The inventive reaction sequence can be applied, for example, to exploit by the combinatorial approaches of the $i(split and mix) concept.
(FR) Dans cette invention, on fait état d'une étude sur la séquence de réactions en phase solide, appropriée à la formation d'une diversité moléculaire sur des hétérocycles courts du type pyrazole et isoxazole. Pour chaque réaction, on a mis au point des conditions appropriées en phase solide, et on a utilisé plusieurs agents réactifs (éléments structuraux) dans le but d'appréhender l'étendue de l'applicabilité du système. On peut appliquer la séquence de réactions de l'invention, par exemple, pour exploiter des approches combinatoires du concept 'scinder et mélanger'.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996075642