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1. (WO1997018798) PROMPT-RELEASE PHARMACEUTICAL COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018798 International Application No.: PCT/EP1996/005127
Publication Date: 29.05.1997 International Filing Date: 21.11.1996
Chapter 2 Demand Filed: 16.06.1997
IPC:
A61K 9/00 (2006.01) ,A61K 9/16 (2006.01) ,A61K 9/20 (2006.01) ,A61K 9/46 (2006.01) ,A61K 9/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
46
effervescent
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
Applicants:
RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY [CH/CH]; C.so San Gottardo 54 CH-6830 Chiasso, CH
Inventors:
SANTUS, Giancarlo; IT
GOLZI, Roberto; IT
Agent:
GERVASI, Gemma; Notarbartolo & Gervasi S.r.l. Corso di Porta Vittoria, 9 I-20122 Milano, IT
Priority Data:
MI95A00242722.11.1995IT
Title (EN) PROMPT-RELEASE PHARMACEUTICAL COMPOSITIONS
(FR) COMPOSITIONS PHARMACEUTIQUES A LIBERATION RAPIDE
Abstract:
(EN) The present invention is represented by a prompt-release pharmaceutical composition, suitable in particular for oral use, comprising: a) a plurality of nuclei having dimensions between 50 and 500 $g(m)m, selected among microcrystals of the active ingredient and microgranules containing at least one active ingredient and at least one pharmaceutically acceptable excipient; b) a lipidic coating comprising a lipidic material sprayed in the melted state onto the said nuclei, and optionally at least one hydrophilic additive; c) a vehicle comprising one or more pharmaceutically acceptable excipients. The coated micronuclei can form a suspension which can be reconstituted by the patient immediately before use by simply adding the suspending phase, or formed into tables or solid aggregates.
(FR) L'invention concerne une composition pharmaceutique à libération rapide, convenant en particulier à une administration orale. Cette composition contient: (a) plusieurs noyaux de 50 à 500 $g(m)m, qui sont soit des microcristaux de l'ingrédient actif, soit des microgranules contenant au moins un ingrédient actif et au moins un excipient acceptable sur le plan pharmaceutique; (b) un enrobage lipidique comprenant un composé lipidique pulvérisé à l'état fondu sur les noyaux et, éventuellement, au moins un additif hydrophile; (c) un vecteur comprenant un ou plusieurs excipients acceptables sur le plan pharmaceutique. Les micronoyaux enrobés peuvent former une suspension qui peut être reconstituée par le patient juste avant l'utilisation, simplement par addition de la phase de suspension, ou être mis sous la forme de comprimés ou d'agrégats solides.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862421JP2000500477 AU1996076948