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1. (WO1997018329) EFFICIENT METHOD OF DETECTING AN INFECTIOUS AGENT IN BLOOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018329 International Application No.: PCT/US1996/018077
Publication Date: 22.05.1997 International Filing Date: 14.11.1996
Chapter 2 Demand Filed: 22.05.1997
IPC:
C12Q 1/68 (2006.01) ,C12Q 1/70 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
Applicants:
RAGLAND, William, L. [US/US]; US
GOODWIN, Mark, A. [US/US]; US
NOVAK, Renata [HR/US]; US
Inventors:
RAGLAND, William, L.; US
GOODWIN, Mark, A.; US
NOVAK, Renata; US
Agent:
JOHNSON, James, Dean ; Jones & Askew 37th floor 191 Peachtree Street, N.E. Atlanta, GA 30303-1769, US
Priority Data:
60/006,69814.11.1995US
Title (EN) EFFICIENT METHOD OF DETECTING AN INFECTIOUS AGENT IN BLOOD
(FR) PROCEDE EFFICACE DE DETECTION D'UN AGENT INFECTIEUX DANS LE SANG
Abstract:
(EN) The present invention provides a method for detecting the presence of a predetermined infectious agent in a human or animal subject comprising obtaining a preselected portion of a whole blood sample containing at least one intact blood cell from the subject and detecting the presence of a nucleic acid from the predetermined infectious agent in the intact blood cell by nucleic acid hybridization. The preselected portion of the blood sample can include any portion which contains at least one intact blood cell, for example a peripheral blood smear or cytospin buffy coat preparation. The intact blood cell can be any blood cell including, but not limited to white blood cells and red blood cells. In one embodiment, the blood cell is a lymphocyte.
(FR) La présente invention concerne un procédé de detection de la présence d'un agent infectieux prédéterminé chez un sujet humain ou animal, consistant à prélever sur le sujet une partie présélectionnée d'un échantillon de sang total contenant au moins un globule sanguin intact, et à détecter la présence d'un acide nucléique provenant de l'agent infectieux prédéterminé dans le globule sanguin intact par hybridation d'acide nucléique. La partie présélectionnée de l'échantillon de sang peut comporter n'importe quelle partie contenant au moins un globule sanguin intact, par exemple une préparation de frottis de sang périphérique ou de couche leucocytaire de cytospine. Le globule sanguin intact peut être n'importe quel globule sanguin y compris, de façon non exhaustive, des globules blancs et des globules rouges. Dans un mode de réalisation, le globule sanguin est un lymphocyte.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0954597CA2231729AU1997010751