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1. (WO1997018236) MIMOTOPES AND ANTI-MIMOTOPES OF HUMAN PLATELET GLYCOPROTEIN Ib/IX
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018236 International Application No.: PCT/US1996/017882
Publication Date: 22.05.1997 International Filing Date: 08.11.1996
Chapter 2 Demand Filed: 13.06.1997
IPC:
C07K 14/705 (2006.01) ,C07K 16/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK [US/US]; P.O. Box 9 Albany, NY 12201-0009, US
Inventors:
MILLER, Jonathan, L.; US
LYLE, Vicki, A.; US
Agent:
BRAMAN, Susan, J.; Jaeckle Fleischmann & Mugel, LLP 39 State Street Rochester, NY 14614-1310, US
Priority Data:
08/556,59713.11.1995US
Title (EN) MIMOTOPES AND ANTI-MIMOTOPES OF HUMAN PLATELET GLYCOPROTEIN Ib/IX
(FR) MIMOTOPES ET ANTI-MIMOTOPES DE LA GLYCOPROTEINE PLAQUETTAIRE HUMAINE Ib/IX
Abstract:
(EN) The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.
(FR) La présente invention se rapporte à un peptide isolé qui simule un site de liaison d'un anticorps monoclonal, ce dernier reconnaissant un épitope dans le complexe de la glycoprotéine plaquettaire humaine Ib/IX. Ce peptide est appelé un mimotope. L'invention se rapporte également à une molécule isolée capable de se fixer au peptide ou au mimotope, cette molécule pouvant être un anticorps, un second peptide, un glucide ou autres molécules naturelles ou synthétisées chimiquement. Cette molécule isolée est appelée un anti-mimotope. L'invention se rapporte spécifiquement à des mimotopes simulant le site de liaison de l'anticorps monoclonal C-34 et SZ-2, ainsi qu'à des anti-mimotopes dirigés contre les mimotopes C-34.
Designated States: CA, CN, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0876396JP2001511111 CN1202175CA2234661