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1. (WO1997018235) PEPTIDE CONJUGATES, USE THEREOF AS A DRUG, AND COMPOSITIONS CONTAINING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018235 International Application No.: PCT/FR1996/001811
Publication Date: 22.05.1997 International Filing Date: 15.11.1996
Chapter 2 Demand Filed: 13.06.1997
IPC:
A61K 8/36 (2006.01) ,A61K 8/64 (2006.01) ,A61K 38/00 (2006.01) ,A61Q 19/00 (2006.01) ,C07K 5/093 (2006.01) ,C07K 5/11 (2006.01) ,C07K 7/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
33
containing oxygen
36
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
64
Proteins; Peptides; Derivatives or degradation products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
093
the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
11
the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
Applicants:
INSTITUT EUROPEEN DE BIOLOGIE CELLULAIRE [FR/FR]; Villa Missouri 18, Avenue de l'Europe F-31520 Ramonville-Saint-Agne, FR (AllExceptUS)
DUSSOURD D'HINTERLAND, Lucien [FR/FR]; FR (UsOnly)
PINEL, Anne-Marie [FR/FR]; FR (UsOnly)
Inventors:
DUSSOURD D'HINTERLAND, Lucien; FR
PINEL, Anne-Marie; FR
Agent:
MARTIN, Jean-Jacques ; Cabinet Regimbeau 26, avenue Kléber F-75116 Paris, FR
Priority Data:
95/1354315.11.1995FR
Title (EN) PEPTIDE CONJUGATES, USE THEREOF AS A DRUG, AND COMPOSITIONS CONTAINING SAME
(FR) CONJUGUES PEPTIDIQUES, LEUR UTILISATION A TITRE DE MEDICAMENT ET COMPOSITIONS LES CONTENANT
Abstract:
(EN) Peptide conjugates including a sequence of at least three amino acids selected from Lys-Lys-Gly, Gly-His-Lys and Glu-His-Lys, wherein 'Lys' is Lysine or a halogenated derivative thereof, or a methylated Lysine derivative, particularly Methyl-Lysine and Dihydrobromo-Methyl-Lysine, said amino acids optionally being in D, L or DL form, and said sequence being chemically or physically conjugated with at least one compound selected from monocarboxylic acids of general formula (I): HOOC-R, or alcohol, aldehyde or amide derivatives thereof, and dicarboxylic acids of general formula (II): HOOC-R1-COOH, are disclosed. The use of such conjugates as a drug, and pharmaceutical or cosmetic compositions containing said conjugates, are also disclosed.
(FR) L'invention concerne des conjugués peptidiques comprenant une séquence d'au moins 3 acides aminés choisis parmi Lys-Lys-Gly, Gly-His-Lys et Glu-His-Lys, dans laquelle 'Lys' représente la Lysine ou un dérivé halogéné de la Lysine, ou un dérivé méthylé de la Lysine, notamment Méthyl-Lysine et Dihydrobromo-Méthyl-Lysine, les acides aminés pouvant être sous la forme D, L ou DL; ladite séquence étant conjuguée chimiquement ou physiquement avec au moins un composé sélectionné parmi les acides monocarboxyliques de formule générale (I): HOOC-R, ainsi que leurs dérivés alcool, aldéhyde ou amide; les acides dicarboxyliques de formule générale (II): HOOC-R1-COOH. Elle concerne également leur utilisation à titre de médicament et des compositions pharmaceutiques ou cosmétologiques les contenant.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
ES2193272EP0869969JP2000512613 CA2237993DE000069627019AU1996076831
FR2741075