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1. (WO1997018216) PRODUCTION OF A SALT OF CLAVULANIC ACID
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018216 International Application No.: PCT/EP1996/005015
Publication Date: 22.05.1997 International Filing Date: 14.11.1996
Chapter 2 Demand Filed: 01.04.1997
IPC:
A61K 31/431 (2006.01) ,C07D 503/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
429
condensed with heterocyclic ring systems
43
Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
431
containing further heterocyclic ring systems, e.g. ticarcillin, azlocillin, oxacillin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
503
Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Applicants:
BIOCHEMIE GESELLSCHAFT MBH [AT/AT]; A-6250 Kundl, AT (AllExceptUS)
WAGNER, Helmut [AT/AT]; AT (UsOnly)
Inventors:
WAGNER, Helmut; AT
Agent:
WYMANN, Gerard ; Sandoz Technology Ltd. Patents & Trademarks Division Lichtstrasse 35 CH-4002 Basle, CH
Priority Data:
A 1867/9515.11.1995AT
Title (EN) PRODUCTION OF A SALT OF CLAVULANIC ACID
(FR) PRODUCTION D'UN SEL DE L'ACIDE CLAVULANIQUE
Abstract:
(EN) Process for the production of alkali salts of clavulanic acid of formula (I) by conversion of clavulanic acid into a pharmaceutically acceptable salt of clavulanic acid which is characterised in that the conversion is carried out in n-butanol or iso-butanol (2-methyl-1-propanol) as a solvent; and a potassium salt of clavulanic acid containing n-butanol or iso-butanol.
(FR) Ce procédé de production de sels alcalins de l'acide clavulanique répondant à la formule (I) consiste à convertir de l'acide clavulanique en un sel de cet acide, acceptable sur le plan pharmacologique, ce procédé étant caractérisé en ce que cette conversion s'effectue dans du n-butanol ou de l'iso-butanol (2-méthyl-1-propanol) en tant que solvant. On décrit également un sel potassique de l'acide clavulanique contenant du n-butanol ou de l'iso-butanol.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1998-1491NO19982107SK64098TR1998/00860MXPA/a/1998/003887SG53266
VN2907IL124353EP0874855RU02179171VN4166 1-1998-00390US6133441
JP4319252 CN1204337CA2237763KR1019990067480NZ322485AU1996076250