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1. (WO1997018211) PROCESS FOR THE PREPARATION OF 9-[(2-HYDROXYETHOXY)METHYL]GUANINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018211 International Application No.: PCT/EP1996/004882
Publication Date: 22.05.1997 International Filing Date: 06.11.1996
Chapter 2 Demand Filed: 10.06.1997
IPC:
C07D 473/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
Applicants:
ARCHIMICA S.P.A. [IT/IT]; Viale Europa, 11 I-21040 Origgio, IT (AllExceptUS)
BELLANI, Piero [IT/IT]; IT (UsOnly)
Inventors:
BELLANI, Piero; IT
Agent:
DRAGOTTI, Gianfranco; Saic Brevetti S.r.l. Galleria San Babila, 4/D I-20122 Milano , IT
Priority Data:
MI95A00233314.11.1995IT
Title (EN) PROCESS FOR THE PREPARATION OF 9-[(2-HYDROXYETHOXY)METHYL]GUANINE
(FR) PROCEDE DE PREPARATION DE 9-[(2-HYDROXYETHOXY)METHYL]GUANINE
Abstract:
(EN) There is described a process for the preparation of acyclovir by hydrolysis of N2-acetyl-9-(2-acetoxyethoxymethyl)guanine with monoethanolamine and isolation of acyclovir by neutralization with an acid and filtration. There is furthermore described a method for the purification of acyclovir by transformation of it into one of its alkali metal salts and neutralization of the alkali metal salt thus obtained.
(FR) On décrit un procédé de préparation d'acyclovir, lequel consiste à hydrolyser une N2-acétyl-9-(2-acétoxyéthoxyméthyl)guanine avec une monoéthanolamine, puis à isoler l'acyclovir en neutralisant avec un acide, et enfin à filtrer. On décrit en outre un procédé de purification de l'acyclovir, lequel consiste à transformer celui-ci en un de ses sels métalliques alcalins, puis à neutraliser le sel métallique alcalin ainsi obtenu.
Designated States: AM, AU, BB, BG, BR, BY, CA, CN, CZ, EE, GE, HU, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LV, MD, MG, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SI, SK, TJ, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862570AU1996075677