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1. (WO1997018202) SUBSTITUTED PIPERIDINE DERIVATIVES AS SELECTIVE AGONISTS OF 5-HT RECEPTORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018202 International Application No.: PCT/GB1996/002765
Publication Date: 22.05.1997 International Filing Date: 13.11.1996
Chapter 2 Demand Filed: 25.04.1997
IPC:
C07D 521/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
521
Heterocyclic compounds containing unspecified hetero rings
Applicants:
MERCK SHARP & DOHME LIMITED [GB/GB]; Hertford Road Hoddesdon Hertfordshire EN11 9BU, GB (AllExceptUS)
CASTRO PINEIRO, Jose Luis [ES/GB]; GB (UsOnly)
COLLINS, Ian, James [GB/GB]; GB (UsOnly)
MACLEOD, Angus, Murray [GB/GB]; GB (UsOnly)
MOYES, Christopher, Richard [GB/GB]; GB (UsOnly)
ROWLEY, Michael [GB/GB]; GB (UsOnly)
SHOWELL, Graham, Andrew [GB/GB]; GB (UsOnly)
Inventors:
CASTRO PINEIRO, Jose Luis; GB
COLLINS, Ian, James; GB
MACLEOD, Angus, Murray; GB
MOYES, Christopher, Richard; GB
ROWLEY, Michael; GB
SHOWELL, Graham, Andrew; GB
Agent:
THOMPSON, John; Merck & Co., Inc. European Patent Dept. Terlings Park, Eastwick Road Harlow Essex CM20 2QR, GB
Priority Data:
9523460.516.11.1995GB
Title (EN) SUBSTITUTED PIPERIDINE DERIVATIVES AS SELECTIVE AGONISTS OF 5-HT RECEPTORS
(FR) DERIVES SUBSTITUES DE LA PIPERIDINE COMME AGONISTES SELECTIFS POUR LES RECEPTEURS 5-HT
Abstract:
(EN) A compound of formula (I), or a salt or prodrug thereof, wherein G is attached at position 3 or 4 of the piperidine ring and represents halogen or C1-6 alkoxy; R1 represents C3-6 alkenyl, C3-6 alkynyl, aryl(C1-6)alkyl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted; processes for its preparation and its use in therapy, particularly in the treatment of migraine.
(FR) Composé de la formule (I), sel ou précurseur de ce composé. Dans cette formule, G est rattaché en position 3 ou 4 au noyau pipéridine, et représente halogène ou alcoxy C1-6; R1 représente alcényle C3-6, alcynyle C3-6, arylalkyle C1-6 ou hétéroarylalkyle C1-6, tous ces groupes pouvant éventuellement être substitués. L'invention concerne également des procédés pour préparer ce composé et son utilisation thérapeutique, en particulier pour le traitement de migraines.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862568US6048878CA2236832AU1996075785