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1. (WO1997018188) BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018188 International Application No.: PCT/US1996/018172
Publication Date: 22.05.1997 International Filing Date: 13.11.1996
Chapter 2 Demand Filed: 01.05.1997
IPC:
C07C 259/06 (2006.01) ,C07C 323/60 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
259
Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
04
without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
06
having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50
containing thio groups and carboxyl groups bound to the same carbon skeleton
51
having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60
with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Applicants:
ABBOTT LABORATORIES [US/US]; CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Inventors:
FESIK, Stephen, W.; US
SUMMERS, James, B., Jr.; US
DAVIDSEN, Steven, K.; US
SHEPPARD, George, S.; US
STEINMAN, Douglas, H.; US
CARRERA, George, M., Jr.; US
FLORJANCIC, Alan; US
HOLMS, James, H.; US
Agent:
BROWDER, Monte, R. ; Abbott Laboratories CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Priority Data:
08/555,69014.11.1995US
Title (EN) BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES
(FR) INHIBITEURS DE METALLOPROTEINASES MATRICIELLES, A L'HYDROXAMATE BIPHENYLIQUE
Abstract:
(EN) Compounds of formula (I), or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF$g(a) secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF$g(a) secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF$g(a) secretion.
(FR) L'invention concerne des composés de formule (I) ou un sel pharmaceutiquement acceptable de ceux-ci, qui inhibent la sécrétion des métalloprotéinases matricielles et de TNF$g(a) et sont utiles dans le traitement de pathologies inflammatoires. Elle porte aussi sur des compositions inhibant la sécrétion de métalloprotéinases matricielles et de TNF$g(a) et sur une méthode d'inhibition de la sécrétion de métalloprotéinases matricielles et de TNF$g(a).
Designated States: AU, CA, IL, JP, KR, MX
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1998/003809IL123502ES2196190EP0874808JP2002504073 CA2236773
KR1019990067573AU1996077296