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1. (WO1997018184) FLUORINATED PROPRANOLOL AND RELATED METHODS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018184 International Application No.: PCT/US1996/017679
Publication Date: 22.05.1997 International Filing Date: 16.11.1996
Chapter 2 Demand Filed: 11.06.1997
IPC:
C07C 217/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02
having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
28
having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
30
having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
Applicants:
THE GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER [US/US]; Ross Hall, Room 402 2300 Eye Street, N.W. Washington, DC 20037, US
Inventors:
WEGLICKI, William, B.; US
MAK, I., Tong; US
ABOUL-ENEIN, Hassan, Y.; US
Agent:
FIELDS, Debra; Office of general Counsel, George Wshington University, 2121 Eye Street, NW. Suite 707 Washington, DC 20052, US
Priority Data:
60/006,83516.11.1995US
60/008,79018.12.1995US
Title (EN) FLUORINATED PROPRANOLOL AND RELATED METHODS
(FR) PROPANOLOL FLUORE ET METHODES ASSOCIEES
Abstract:
(EN) Fluorinated beta blockers, such as propranolol, are presented with amplified antioxidant effects and various levels of beta blocking effects. Mixtures are also presented of fluorinated antioxidant drugs, such as propranolol, with flurinated antioxidant non-beta blocking analogs of the same drugs. Methods of treatement of disease by the use of the fluorinated drugs and the mixtures are presented.
(FR) L'invention concerne des bêta-bloquants fluorés, tels que le propanolol, présentant une activité antioxydante accrue et des niveaux variables d'activité bêta-bloquante. Elle concerne également des mélanges de médicaments antioxydants fluorés, tels que le propanolol, avec des analogues antioxydants fluorés non bêta-bloquants des mêmes médicaments. Elle concerne enfin des méthodes de traitement de certaines pathologies à l'aide desdits médicaments fluorés et de leurs mélanges.
Designated States: JP
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0883596JP2000500451DK0883596