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1. (WO1997018024) SEPARATION OF MOLECULES FROM DILUTE SOLUTIONS USING COMPOSITE CHROMATOGRAPHY MEDIA HAVING HIGH DYNAMIC SORPTIVE CAPACITY AT HIGH FLOW RATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/018024 International Application No.: PCT/US1996/017345
Publication Date: 22.05.1997 International Filing Date: 30.10.1996
Chapter 2 Demand Filed: 12.06.1997
IPC:
B01D 15/08 (2006.01) ,C07K 1/18 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
15
Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08
Selective adsorption, e.g. chromatography
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
16
by chromatography
18
Ion-exchange chromatography
Applicants:
BIOSEPRA, INC. [US/US]; 111 Locke Drive Marlborough, MA 01752, US
Inventors:
COFFMAN, Jonathan, L.; US
GIROT, Pierre; FR
BOSCHETTI, Egisto; FR
Agent:
FANUCCI, Allan, A. ; Pennie & Edmonds 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
556,31313.11.1995US
Title (EN) SEPARATION OF MOLECULES FROM DILUTE SOLUTIONS USING COMPOSITE CHROMATOGRAPHY MEDIA HAVING HIGH DYNAMIC SORPTIVE CAPACITY AT HIGH FLOW RATES
(FR) SEPARATION DE MOLECULES DANS DES SOLUTIONS DILUEES AU MOYEN DE MILIEUX COMPOSITES DE CHROMATOGRAPHIE AYANT UNE CAPACITE DE SORPTION DYNAMIQUE ELEVEE A FORTS DEBITS
Abstract:
(EN) This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.
(FR) Cette invention se rapporte de manière générale à des milieux modifiés, poreux, solides de chromatographie ainsi qu'à des procédés de préparation et d'utilisation de ces milieux. L'invention se rapporte plus particulièrement à des milieux de chromatographie constitués de supports d'oxydes minéraux poreux, de supports polymères ou de supports d'oxydes minéraux enrobés de polymères, lesdits milieux étant caractérisés par une forte capacité de sorption réversible et par des taux élevés de transferts de masse intra-particules. Afin d'empêcher une adsorption non spécifique de biomolécules ou une interaction avec des biomolécules, on peut rendre ces supports passifs en utilisant un mélange pour passivation comportant un monomère principal, un monomère passivant et un agent de réticulation, ledit mélange supprimant, de manière substantielle, l'interaction non spécifique indésirable avec les biomolécules au cours de la polymérisation.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, FI, GE, HU, IL, IS, JP, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996074825