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1. (WO1997017994) TREATMENT OF DIABETES WITH A GLUCOKINASE GENE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017994 International Application No.: PCT/ES1996/000216
Publication Date: 22.05.1997 International Filing Date: 15.11.1996
IPC:
A61K 48/00 (2006.01) ,C12N 9/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
12
transferring phosphorus containing groups, e.g. kinases (2.7)
Applicants:
UNIVERSIDAD AUTONOMA DE BARCELONA [ES/ES]; Edifici V E-08193 Bellaterra, ES (AllExceptUS)
BOSCH TUBERT, Fátima [ES/ES]; ES (UsOnly)
VALERA ABRIL, Alfons [ES/ES]; ES (UsOnly)
Inventors:
BOSCH TUBERT, Fátima; ES
VALERA ABRIL, Alfons; ES
Agent:
ELZABURU MARQUEZ, Alberto; Miguel Angel, 21 E-28010 Madrid, ES
Priority Data:
08/559,36816.11.1995US
Title (EN) TREATMENT OF DIABETES WITH A GLUCOKINASE GENE
(ES) TRATAMIENTO DE LA DIABETES CON UN GEN DE GLUCOQUINASA
(FR) TRAITEMENT DU DIABETE A L'AIDE D'UN GENE DE GLUCOKINASE
Abstract:
(EN) Process for treating a diabetic patient. The process comprises administering to the patient a DNA segment which includes a glucokinase gene and a promotor sequence. In the DNA segment, the promotor sequence is operatively linked to the glucokinase gene and is efficient for the expression of a therapeutically efficient quantity of glucokinase in the diabetic patient.
(ES) Un procedimiento para tratar a un paciente diabético. El procedimiento incluye la operación de administrar al paciente un segmento de ADN que incluye un gen de glucoquinasa y una secuencia de promotor. En el segmento de ADN, la secuencia de promotor está enlazada operativamente al gen de glucoquinasa y es eficaz para la expresión de una cantidad terapéuticamente eficaz de glucoquinasa en el paciente diabético.
(FR) Procédé de traitement d'un patient diabétique. Le procédé consiste à administrer au patient un segment d'ADN qui comprend un gène de glucokinase et une séquence de promoteur. Dans le segment d'ADN, la séquence de promoteur est liée de manière effective au gène de glucokinase et est efficace pour l'expression d'une quantité thérapeutiquement efficace de glucokinase chez le patient souffrant de diabète.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)
Also published as:
EP0820773JPH10512762 CA2236332AU1996075726