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1. (WO1997017970) KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017970 International Application No.: PCT/JP1996/003339
Publication Date: 22.05.1997 International Filing Date: 14.11.1996
Chapter 2 Demand Filed: 19.12.1996
IPC:
A61K 31/5415 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
5415
ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
Applicants:
YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP/JP]; 3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103, JP (AllExceptUS)
SHISHIKURA, Jun-ichi [JP/JP]; JP (UsOnly)
INAMI, Hiroshi [JP/JP]; JP (UsOnly)
YASUNAGA, Tomoyuki [JP/JP]; JP (UsOnly)
HIRANO, Masaaki [JP/JP]; JP (UsOnly)
SAKAMOTO, Shuichi [JP/JP]; JP (UsOnly)
OHNO, Kazushige [JP/JP]; JP (UsOnly)
OKADA, Masamichi [JP/JP]; JP (UsOnly)
TSUKAMOTO, Shin-ichi [JP/JP]; JP (UsOnly)
Inventors:
SHISHIKURA, Jun-ichi; JP
INAMI, Hiroshi; JP
YASUNAGA, Tomoyuki; JP
HIRANO, Masaaki; JP
SAKAMOTO, Shuichi; JP
OHNO, Kazushige; JP
OKADA, Masamichi; JP
TSUKAMOTO, Shin-ichi; JP
Agent:
NAGAI, Shozo ; Yamanouchi Pharmaceutical Co., Ltd. Patent & Information Dept. 17-1, Hasune 3-chome Itabashi-ku Tokyo 174-8612, JP
Priority Data:
7/29685715.11.1995JP
Title (EN) KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES
(FR) INHIBITEURS DE LA NEUROTOXICITE DE L'ACIDE KAINIQUE ET DERIVES DE LA PYRIDOTHIAZINE
Abstract:
(EN) Neuron protective agents on the basis of the inhibition of neuronotoxicity of kainic acid and compounds useful as such agents. Pyridothiazine derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof and neuronotoxicity inhibitors containing as the active ingredient these compounds or pharmaceutically acceptable salts thereof, wherein A represents a pyridine ring; formula (II) represents formula (III) or formula (IV); and R1, R2, R3, R4 and R5 are the same or different and each represents hydrogen, optionally substituted lower alkyl, cycloalkyl, alkenyl, aryl, carboxy or lower alkoxycarbonyl or does not exist, or R2 and R3 together form a nitrogenous heterocycle optionally having a nitrogen atom as another heteroatom, being fused with a benzene ring, or being substituted by lower alkyl.
(FR) Agents de protection neuronale basés sur l'inhibition de la neurotoxicité de l'acide kaïnique et composés utiles en tant qu'agents de protection de ce type. Dérivés de la pyridothiazine de formule générale (I), ou leurs sels pharmaceutiquement acceptables, et inhibiteurs de la neurotoxicité contenant comme agents actifs ces composés ou ces sels pharmaceutiquement acceptables, où A représente un noyau pyridinique; (II) représente (III) ou (IV); et R1, R2, R3, R4 et R5 sont identiques ou différents et représentent hydrogène, alkyle inférieur éventuellement substitué, cycloalkyle, alcényle, aryle, carboxy ou alcoxycarbonyle, ou bien n'existent pas, ou bien R2 et R3 ensemble constituent un hétérocycle azoté possédant éventuellement comme autre hétéroatome un atome d'azote, condensé avec un noyau benzénique ou substitué par un alkyle inférieur.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP0878196US6133258CN1202109CA2237911KR1019990067528AU1996075870