Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1997017949) BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017949 International Application No.: PCT/US1996/018496
Publication Date: 22.05.1997 International Filing Date: 15.11.1996
Chapter 2 Demand Filed: 20.05.1997
IPC:
A61K 31/155 (2006.01) ,A61K 31/341 (2006.01) ,C07C 257/18 (2006.01) ,C07C 259/18 (2006.01) ,C07D 307/54 (2006.01) ,C07D 307/68 (2006.01) ,C07D 333/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341
not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
257
Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
10
with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
18
having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
259
Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
12
with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
18
having carbon atoms of hydroxyamidine groups bound to carbon atoms of six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
38
with substituted hydrocarbon radicals attached to ring carbon atoms
54
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
56
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
68
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
24
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 300 Bynum Hall Chapel Hill, NC 27599, US
GEORGIA STATE UNIVERSITY [US/US]; University Plaza Atlanta, GA 30303-3083, US
Inventors:
HALL, James, Edwin; US
TIDWELL, Richard, Ray; US
BOYKIN, David, Withers; US
Agent:
SIBLEY, Kenneth, D. ; Myers Bigel Sibley & Sajovec, L.L.P. P.O. Box 37428 Raleigh, NC 27627, US
Priority Data:
08/558,71616.11.1995US
Title (EN) BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS
(FR) PROMEDICAMENTS A BASE DE BENZAMIDOXIME ACTIFS CONTRE LA PNEUMOCYSTITE
Abstract:
(EN) A method of treating $i(Pneumocystis carinii) pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a $i(bis)-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-$i(P. carinii) activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.
(FR) La présente invention concerne une thérapie contre la pneumonie par $i(Pneumocystis carinii) chez un sujet justifiant d'une telle thérapie. La thérapie consiste en l'administration par voie orale au sujet d'un $i(bis)-benzamidoxime, ou de l'un de ses sels pharmaceutiquement acceptables, qui est réduit chez le sujet de façon à produire une benzamidine dotée d'activité anti-$i(P. carinii). Sous une autre réalisation, la thérapie de la présente invention peut consister en l'administration par voie intraveineuse au sujet d'un composé actif tel que celui de l'invention. L'invention concerne également des formulations pharmaceutiques et des composés actifs convenant pour la mise en ÷uvre de la présente invention.
Designated States: AU, CA, IL, JP, KR
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0861071EP1561463JP2000500469 CA2237650CA2549534AU1997011605
AU2000062473AU2003266476