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1. (WO1997017455) COMMERCIAL PRODUCTION OF AVIDIN IN PLANTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017455 International Application No.: PCT/US1996/017091
Publication Date: 15.05.1997 International Filing Date: 31.10.1996
Chapter 2 Demand Filed: 16.05.1997
IPC:
C07K 14/46 (2006.01) ,C07K 14/465 (2006.01) ,C12N 15/82 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
465
from birds
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
82
for plant cells
Applicants:
HOWARD, John [US/US]; US
Inventors:
HOWARD, John; US
BASZCZYNSKI, Chris; US
HOOD, Elizabeth; US
MADDOCK, Sheila; US
MEYER, Terry, EuClaire; US
REGISTER, James, C., III; US
WITCHER, Derrick; US
Agent:
BENT, Stephen, A. ; Foley & Lardner Suite 500 3000 K Street, N.W. Washington, DC 20007-5109, US
Priority Data:
08/554,58606.11.1995US
Title (EN) COMMERCIAL PRODUCTION OF AVIDIN IN PLANTS
(FR) PRODUCTION COMMERCIALE D'AVIDINE DANS DES PLANTES
Abstract:
(EN) A method for commercial production of avidin entails heterologous expression of the protein in plants, in native conformation, at an expression level such that avidin represents at least 0.1 % of total extracted protein. A genetic map of the integration locus allows for the identification of the avidin-expressing plant. Genetic loci on a plant chromosome are revealed that support high levels of avidin expression and that can be used as a site of integration for high level expression of other genes of interest.
(FR) L'invention concerne un procédé de production commerciale de l'avidine, qui consiste en une expression hétérologue de la protéine dans des plantes, en conformation native, à un niveau d'expression tel que l'avidine représente au moins 0,1 % de la protéine extraite totale. Une carte génétique du locus d'intégration permet d'identifier la plante exprimant l'avidine. Le procédé permet d'identifier sur un chromosome de plante les loci génétiques qui offrent des niveaux élevés d'expression pour l'avidine et que l'on peut utiliser comme site d'intégration pour l'expression, à un niveau élevé, d'autres gènes présentant de l'intérêt.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862641CA2232736AU1996074734