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1. (WO1997017433) TISSUE-SPECIFIC AND TARGET RNA-SPECIFIC RIBOZYMES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017433 International Application No.: PCT/US1996/018088
Publication Date: 15.05.1997 International Filing Date: 08.11.1996
Chapter 2 Demand Filed: 09.06.1997
IPC:
A61K 38/00 (2006.01) ,A61K 48/00 (2006.01) ,C12N 15/11 (2006.01) ,C12N 15/88 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88
using micro-encapsulation, e.g. using liposome vesicle
Applicants:
MEDICAL UNIVERSITY OF SOUTH CAROLINA [US/US]; 171 Ashley Avenue Charleston, SC 29464, US
PENN STATE RESEARCH FOUNDATION [US/US]; 304 Old Main University Park, PA 16802, US
Inventors:
NORRIS, James, S.; US
CLAWSON, Gary, A.; US
Agent:
SPRATT, Gwendolyn, D. ; Needle & Rosenberg Suite 1200 127 Peachtree Street, N.E. Atlanta, GA 30303, US
Priority Data:
08/554,36908.11.1995US
Title (EN) TISSUE-SPECIFIC AND TARGET RNA-SPECIFIC RIBOZYMES
(FR) RIBOZYMES SPECIFIQUES DE TISSUS OU D'ARN CIBLE
Abstract:
(EN) The invention provides tissue-specific and target RNA-specific ribozymes. These ribozymes can be used to destroy target-specific neoplasms and to treat viral infections, among other uses. The ribozymes of the present invention comprise a 5' autocatalytically cleaving ribozyme sequence, a catalytic ribozyme comprising a target RNA-specific binding site and a 3' autocatalytically cleaving ribozyme. The invention also provides nucleic acids which encode the ribozymes of the invention. These nucleic acids can be used to express the ribozymes of the invention at the selected site. Methods of treating disease by administering the ribozymes are provided.
(FR) On décrit des ribozymes, spécifiques d'un tissu ou d'un ARN cible, pouvant s'utiliser pour détruire des néoplasmes spécifiques d'une cible et pour traiter des infections virales, entre autres utilisations. Ces ribozymes comprennent une séquence de ribozymes à coupure autocatalytique en 5', un ribozyme catalytique comprenant un site de liaison spécifique d'un ARN cible et un ribozyme à coupure autocatalytique en 3'. On décrit aussi des acides nucléiques qui codent de tels ribozymes et peuvent servir à exprimer les ribozymes décrits sur un site choisi. On décrit enfin des procédés concernant le traitement de maladies et consistant à administrer ces ribozymes.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0866852EP1561815JP2007084550JP2000500967 CN1207769CA2236998
AU1996077272