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1. (WO1997017430) RECONSTITUTED MINERALIZED CARTILAGE TISSUE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017430 International Application No.: PCT/CA1996/000729
Publication Date: 15.05.1997 International Filing Date: 05.11.1996
Chapter 2 Demand Filed: 28.05.1997
IPC:
C12N 15/09 (2006.01) ,A61K 35/32 (2006.01) ,A61L 27/38 (2006.01) ,A61P 19/02 (2006.01) ,C12N 15/85 (2006.01) ,C12N 5/00 (2006.01) ,C12N 5/077 (2010.01) ,C12N 5/10 (2006.01) ,C12Q 1/02 (2006.01) ,A61K 35/12 (2006.01) ,A61K 48/00 (2006.01)
C CHEMISTRY; METALLURGY
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BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
32
Bones; Tendons; Teeth; Cartilage
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
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METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
38
Animal cells
A HUMAN NECESSITIES
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MEDICAL OR VETERINARY SCIENCE; HYGIENE
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SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
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15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
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Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
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5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
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BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
MOUNT SINAI HOSPITAL CORPORATION [CA/CA]; 600 University Avenue Toronto, Ontario M5G 1X5, CA (AllExceptUS)
KANDEL, Rita [CA/CA]; CA (UsOnly)
Inventors:
KANDEL, Rita; CA
Agent:
BERESKIN & PARR; 40 King Street West P.O. Box 401 Toronto, Ontario M5H 3Y2, CA
Priority Data:
08/706,62506.09.1996US
60/007,27906.11.1995US
Title (EN) RECONSTITUTED MINERALIZED CARTILAGE TISSUE
(FR) TISSU CARTILAGINEUX RECONSTITUE ET MINERALISE
Abstract:
(EN) A biological material comprising a continuous layer of cartilaginous tissue reconstituted $i(in vitro) which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized biological material. The mineralized biological material is characterized by having a biochemical composition and physiological organization substantially similar to the deep and contiguous calcified cartilage zones of articular cartilage found in animals $i(in vivo). Methods for preparing the biological materials and methods of using the biological materials are described.
(FR) Matériau biologique comprenant une couche continue de tissu cartilagineux reconstitué $i(in vitro) et contenant des éléments associés à la minéralisation du cartilage. On peut cultiver ce matériau biologique avec un agent minéralisant, afin d'obtenir un matériau biologique minéralisé. Ce matériau biologique minéralisé est caractérisé par le fait qu'il possède une composition biochimique et une organisation physiologique sensiblement similaires aux zones profondes et contiguës de cartilages calcifiés de cartilages articulaires que l'on trouve chez l'animal $i(in vivo). Des procédés de préparation et d'utilisation de ces matériaux biologiques sont également décrits.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862616US6464729US20100068241JP2002515731 CA2236807AU1996072746