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1. (WO1997017427) NOVEL PROCESS FOR THE PROPAGATION OF B. PERTUSSIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017427 International Application No.: PCT/EP1996/004806
Publication Date: 15.05.1997 International Filing Date: 04.11.1996
Chapter 2 Demand Filed: 26.05.1997
IPC:
A61K 39/00 (2006.01) ,A61K 39/10 (2006.01) ,C07K 14/235 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
10
Brucella; Bordetella, e.g. Bordetella pertussis
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
235
from Bordetella (G)
Applicants:
SMITHKLINE BEECHAM BIOLOGICALS S.A. [BE/BE]; Rue de L'Institut 89 B-1330 Rixensart, BE (AllExceptUS)
COMBERBACH, Martin [GB/BE]; BE (UsOnly)
ROELANTS, Piet [BE/BE]; BE (UsOnly)
Inventors:
COMBERBACH, Martin; BE
ROELANTS, Piet; BE
Agent:
DALTON, Marcus, Jonathan, William; SmithKline Beecham Corporate Intellectual Property Two New Horizons Court Brentford Middlesex TW8 9EP, GB
Priority Data:
9522839.108.11.1995GB
Title (EN) NOVEL PROCESS FOR THE PROPAGATION OF B. PERTUSSIS
(FR) NOUVEAU PROCEDE DE PROPAGATION DU B. PERTUSSIS
Abstract:
(EN) The invention relates to a process for culturing bacteria from the genus Bordetella from which antigens useful in an acellular vaccine may be isolated. The invention results in improved yields of FHA and PT in the culture media and involves culturing the bacteria with specific grades of Polyvinyl alcohol.
(FR) L'invention concerne un procédé de culture d'une bactérie du genre Bordetella, à partir de laquelle on peut isoler des antigènes utiles dans un vaccin acellulaire. L'invention permet d'obtenir des rendements améliorés de FHA (hémaglutinine filamenteuse) et de PT (toxine du pertussis) dans le milieu de culture et implique une culture de la bactérie à l'aide d'alcool polyvinylique présentant des degrés spécifiques.
Designated States: JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0953038JP2000500006