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1. (WO1997017372) PRODUCTION OF ANTIBODIES, AND MEDICAL USES INVOLVING ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017372 International Application No.: PCT/GB1996/002638
Publication Date: 15.05.1997 International Filing Date: 30.10.1996
Chapter 2 Demand Filed: 16.05.1997
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,C07K 16/40 (2006.01) ,C07K 16/42 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42
against immunoglobulins (anti-idiotypic antibodies)
Applicants:
THE BINDING SITE LIMITED [GB/GB]; P.O. Box 4073 Birmingham B29 6AT, GB (AllExceptUS)
BRADWELL, Arthur, Randell [GB/GB]; GB (UsOnly)
Inventors:
BRADWELL, Arthur, Randell; GB
Agent:
BARKER, BRETTELL & DUNCAN; 138 Hagley Road Edgbaston Birmingham B16 9PW, GB
Priority Data:
9522554.603.11.1995GB
9615578.324.07.1996GB
Title (EN) PRODUCTION OF ANTIBODIES, AND MEDICAL USES INVOLVING ANTIBODIES
(FR) PRODUCTION D'ANTICORPS ET APPLICATIONS MEDICALES DANS LESQUELLES LESDITS ANTICORPS SONT UTILISES
Abstract:
(EN) A naive B-cell can be prevented from having a primary immunological response to an antigen if antibodies to the antigen are already present. This can be exploited technologically by tolerising an animal with unwanted antibodies, allowing it to produce desired antibodies that are more specific antibodies than has hitherto been possible. This enables better immunological test kits to be produced. The feature of naive B-cell switch off can also be industrially applied to prevent an immunological response to repeated administrations of physiologically active substances to a patient.
(FR) On peut empêcher la réaction immunologique primaire d'une cellule B naïve à un antigène si les anticorps dirigés contre l'antigène sont toujours présents. On peut exploiter cela sur le plan technologique en rendant un animal tolérant à des anticorps indésirables, ce qui lui permet de produire des anticorps voulus, qui sont des anticorps présentant une spécificité bien supérieure à ce qu'il a été jusqu'à maintenant possible d'atteindre. Ceci permet de préparer de meilleures trousses d'analyse immunologique. On peut également appliquer dans le domaine industriel la caractéristique de mise hors service de la cellule B naïve, afin d'empêcher une réaction immunologique à des administrations répétées de substances actives sur le plan physiologique à un patient.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862584JP2001501579 AU1996073200