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1. (WO1997017362) NOVEL AMINO ACID DERIVATIVES, METHODS OF PRODUCING THEM, AND PHARMACEUTICAL COMPOUNDS CONTAINING THESE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017362 International Application No.: PCT/EP1996/004771
Publication Date: 15.05.1997 International Filing Date: 04.11.1996
Chapter 2 Demand Filed: 26.04.1997
IPC:
A61K 38/00 (2006.01) ,C07K 5/02 (2006.01) ,C07K 5/06 (2006.01) ,C07K 5/078 (2006.01) ,C07K 5/097 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
078
the first amino acid being heterocyclic, e.g. Pro, His, Trp
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
097
the first amino acid being heterocyclic, e.g. Pro, His, Trp, e.g. thyroliberin, melanostatin
Applicants:
BOEHRINGER INGELHEIM KG [DE/DE]; D-55216 Ingelheim, DE
Inventors:
ESSER, Franz; DE
SCHNORRENBERG, Gerd; DE
IGNATOW, Hans-Peter; DE
GIESLER, Guenther; DE
JUNG, Birgit; DE
SPECK, Georg; DE
Priority Data:
195 41 283.406.11.1995DE
Title (DE) NEUE AMINOSÄUREDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
(EN) NOVEL AMINO ACID DERIVATIVES, METHODS OF PRODUCING THEM, AND PHARMACEUTICAL COMPOUNDS CONTAINING THESE COMPOUNDS
(FR) NOUVEAUX DERIVES D'ACIDE AMINE, PROCEDE DE PRODUCTION CORRESPONDANT ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES
Abstract:
(DE) Die Erfindung betrifft neue Aminosäurederivate der allgemeinen Formel (I) R1-R11-A1-A2-NR2R3 und deren pharmazeutisch annehmbare Salze, worin R1, A1, A2, R2, R3 und R11 die in der Beschreibung angegebenen Bedeutungen besitzen sowie deren Herstellung und Verwendung. Die neuen Verbindungen sind wertvolle Neurokinin (Tachykinin)-Antagonisten.
(EN) Disclosed are: novel amino acid derivatives of formula (I) R1-R11-A1-A2-NR2R3 and their pharmacologically tolerable salts, formula (I) in which R1, A1, A2, R2, R3, and R11 have the meanings indicated in the description; and their production and use. The novel compounds are valuable neurokinin (tachykinin) antagonists.
(FR) L'invention concerne de nouveaux dérivés d'acide aminé de la formule générale (I) R1-R11-A1-A2-NR2R3, dans laquelle R1, A1, A2, R2, R3 et R11 ont la signification donnée dans la description. L'invention concerne également leurs sels pharmaceutiquement tolérables, leur production et leur utilisation. Les nouveaux composés sont de précieux antagonistes de la neurokinine (tachykinine).
Designated States: AU, BG, BR, BY, CA, CN, CZ, EE, HU, IL, JP, KR, KZ, LT, LV, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TR, UA, UZ, VN
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
CO4770964EP0871653US6232468JP3912798 JP2000501382 AR04291
CA2234610AU1996075622ID014.878