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1. (WO1997017358) MAMMARY TRANSFORMING PROTEIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017358 International Application No.: PCT/US1995/014540
Publication Date: 15.05.1997 International Filing Date: 08.11.1995
Chapter 2 Demand Filed: 04.06.1997
IPC:
A61K 38/00 (2006.01) ,A61K 48/00 (2006.01) ,C07K 14/82 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82
Translation products from oncogenes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
HUMAN GENOME SCIENCES, INC. [US/US]; 9410 Key West Avenue Rockville, MD 20850-3338, US
Inventors:
NI, Jian; US
YU, Guo-Liang; US
GENTZ, Reiner; US
Agent:
BENSON, Robert, H.; Human Genome Sciences 9410 Key West Avenue Rockville, MD 20850-3338, US
Priority Data:
Title (EN) MAMMARY TRANSFORMING PROTEIN
(FR) PROTEINE DE TRANSFORMATION MAMMAIRE
Abstract:
(EN) A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example cancer, are also disclosed.
(FR) La présente invention concerne une protéine de transformation mammaire humaine et l'ADN (ANR) codant un tel polypeptide ainsi qu'un procédé de production de ce polypeptide par des techniques de recombinaison. L'invention concerne aussi des procédés d'inhibition d'un tel polypeptide pour prévenir ou traiter, ou les deux, la néoplasie. L'invention concerne également des procédés de détermination diagnostique servant à identifier les mutations dans la séquence d'acide nucléique codant un polypeptide de la présente invention et à détecter des modifications du niveau du polypeptide de la présente invention pour détecter des maladies, par exemple le cancer.
Designated States: AU, CA, CN, JP, KR, MX, NZ
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996041053