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1. (WO1997017344) AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017344 International Application No.: PCT/SE1996/001425
Publication Date: 15.05.1997 International Filing Date: 06.11.1996
Chapter 2 Demand Filed: 29.05.1997
IPC:
C07D 409/12 (2006.01) ,C07D 413/12 (2006.01) ,C07D 413/14 (2006.01) ,C07D 471/04 (2006.01) ,C07D 487/04 (2006.01) ,C07D 498/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
ASTRA AKTIEBOLAG [SE/SE]; S-151 85 Södertälje, SE (AllExceptUS)
MACDONALD, James [US/US]; US (UsOnly)
MATZ, James [US/US]; US (UsOnly)
SHAKESPEARE, William [US/US]; US (UsOnly)
Inventors:
MACDONALD, James; US
MATZ, James; US
SHAKESPEARE, William; US
Agent:
ASTRA AKTIEBOLAG; Patent Dept. S-151 85 Södertälje, SE
Priority Data:
60/006,25307.11.1995US
60/006,27607.11.1995US
9600275-325.01.1996SE
9603300-611.09.1996SE
9603301-411.09.1996SE
Title (EN) AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE
(FR) DERIVES D'AMIDINE ET D'ISOTHIO-UREE EN TANT QU'INHIBITEURS DE LA SYNTHASE DE L'OXYDE NITRIQUE
Abstract:
(EN) There are provided novel compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy.
(FR) L'invention, qui porte sur de nouveaux composés répondant à la formule (I) dans laquelle X, R1, R2, R3, R4, et R5 sont tels que défini dans le descriptif, a également trait à leurs isomères optiques et leurs racémiques ainsi qu'à leurs sels acceptables du point de vue pharmaceutique. Cette invention concerne, de surcroît, des techniques visant à la préparation de ces composés, des compositions les contenant ainsi que leur utilisation thérapeutique.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1998-1392IS4725NO19982072SK61098TR1998/00813MXPA/a/1998/003453
SG51992EP0861250US5929085JP2000500132 CN1207098CA2235301
KR1019990067349NZ322227AU1996075927DK0861250