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1. (WO1997017343) INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017343 International Application No.: PCT/US1996/017275
Publication Date: 15.05.1997 International Filing Date: 29.10.1996
Chapter 2 Demand Filed: 29.05.1997
IPC:
C07D 405/12 (2006.01) ,C07D 493/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
AMERICAN HOME PRODUCTS CORPORATION [US/US]; Five Giralda Farms Madison, NJ 07940-0874, US
Inventors:
KANG, Young, Hee; US
STACK, Gary, Paul; US
Agent:
ALICE, Ronald, W.; American Home Products Corporation Patent Law Dept. - 2B One Campus Drive Parsippany, NJ 07054 , US
BROWN, Keith, John, Symons; Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berkshire SL6 0PH, GB
Priority Data:
60/007,28406.11.1995US
Title (EN) INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS
(FR) DERIVES INDOLEALKYLE DE BENZODIOXANMETHYLAMINE UTILES EN TANT QUE LIGANDS DU RECEPTEUR 5-HT1A
Abstract:
(EN) The compounds of formula (I), wherein R1, R4 and R5 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, trifluoromethyl, amino, mono- or di-alkylamino, alkanamido, or alkanesulfonamido; or, R1 is defined as above and R4 and R5, taken together, are ortho substituted methylenedioxy, ethylenedioxy, or propylenedioxy; R2 and R3 are, independently, hydrogen or alkyl; n is 3 or 4; or pharmaceutically acceptable salts thereof, are useful in the treatment of depression and related disorders.
(FR) Cette invention concerne des composés de formule (I). Dans la formule R1, R4 et R5 représentent indépendamment hydrogène, alkyle, alcoxy, aralcoxy, alcanoyloxy, hydroxy, halo, trifluorométhyle, amino, monoalkylamino ou dialkylamino, alcanamido ou alcanesulfonamido; ou bien R1 est défini comme ci-dessus et R4 et R5 pris ensemble représentent méthylènedioxy, éthylènedioxy ou propylènedioxy ortho substitué; R2 et R3 représentent indépendamment hydrogène ou alkyle; n représente 3 ou 4. Ces composés ou leurs sels pharmaceutiquement acceptables sont utiles dans le traitement de la dépression et des troubles associés.
Designated States: AL, AU, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KP, KR, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, UA, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG53599IL124095EP0861248JP2000500136CN1205700CA2236678
KR1019990067303NZ321821AU1996075245DK0861248