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1. (WO1997017341) A PROCESS OF MAKING 3-PHENYL-1-METHYLENEDIOXYPHENYL-INDANE-2-CARBOXYLIC ACID DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017341 International Application No.: PCT/US1996/018465
Publication Date: 15.05.1997 International Filing Date: 08.11.1996
Chapter 2 Demand Filed: 06.06.1997
IPC:
C07D 317/60 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
44
ortho- or peri-condensed with carbocyclic rings or ring systems
46
condensed with one six-membered ring
48
Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
50
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
60
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants:
SMITHKLINE BEECHAM CORPORATION [US/US]; Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US (AllExceptUS)
CLARK, William, Morrow [US/US]; US (UsOnly)
LANTOS, Ivan [US/US]; US (UsOnly)
MILLS, Robert, John [GB/US]; US (UsOnly)
PRIDGEN, Lendon, Norwood [US/US]; US (UsOnly)
TICKNER, Ann, Marie [US/US]; US (UsOnly)
Inventors:
CLARK, William, Morrow; US
LANTOS, Ivan; US
MILLS, Robert, John; US
PRIDGEN, Lendon, Norwood; US
TICKNER, Ann, Marie; US
Agent:
DUSTMAN, Wayne, J. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
60/006,33108.11.1995US
Title (EN) A PROCESS OF MAKING 3-PHENYL-1-METHYLENEDIOXYPHENYL-INDANE-2-CARBOXYLIC ACID DERIVATIVES
(FR) PROCEDE DE PRODUCTION DE DERIVES DE L'ACIDE 3-PHENYL-1-METHYLENEDIOXYPHENYL-INDANE-2-CARBOXYLIQUE
Abstract:
(EN) Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S, 2R, 3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
(FR) L'invention concerne un procédé amélioré pour préparer des dérivés du type cyclopentane fusionné avec un noyau aromatique. Les composés préférés préparés selon cette invention sont des dérivés indane carboxylate et des dérivés cyclopentano pyridine. Les composés particulièrement préférés de cette invention sont l'acide (+)(1S, 2R, 3S)-3-[2-(2-hydroxyéth-1-yloxy)-4-méthoxyphényl]-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels acceptables sur le plan pharmaceutique, ainsi que l'acide (+)(1S,2R,3S)-3-(2-carboxyméthoxy-4-méthoxyphényl)-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels acceptables sur le plan pharmaceutique. L'invention concerne aussi de nouveaux intermédiaires utiles pour préparer ces composés.
Designated States: AL, AM, AU, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KG, KP, KR, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1019397US6143907JP2000500443 CA2236926AU1997010542