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1. (WO1997017340) NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017340 International Application No.: PCT/FR1996/001750
Publication Date: 15.05.1997 International Filing Date: 07.11.1996
Chapter 2 Demand Filed: 03.05.1997
IPC:
C07D 405/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
Applicants:
HOECHST MARION ROUSSEL [FR/FR]; 1 Terrasse Bellini F-92800 Puteaux, FR (AllExceptUS)
HECKMANN, Bertrand [FR/FR]; FR (UsOnly)
JOUQUEY, Simone [FR/FR]; FR (UsOnly)
VEVERT, Jean-Paul [FR/FR]; FR (UsOnly)
ZHANG, Jidong [CN/FR]; FR (UsOnly)
Inventors:
HECKMANN, Bertrand; FR
JOUQUEY, Simone; FR
VEVERT, Jean-Paul; FR
ZHANG, Jidong; FR
Agent:
VIEILLEFOSSE, Jean-Claude; Hoechst Marion Roussel 102, route de Noisy F-93235 Romainville Cédex, FR
Priority Data:
95/1319008.11.1995FR
Title (EN) NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS
(FR) NOUVEAUX DERIVES DE L'IMIDAZOLE, PROCEDE DE PREPARATION, INTERMEDIAIRES OBTENUS, COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION COMME ANTAGONISTES DE L'INDOTHELINE
Abstract:
(EN) Novel compounds of formula (I), wherein R1 is alkyl, A is a sulphur or oxygen atom, R2 is carboxy, tetrazolyl or alkyl, alkoxy and alkylthio substituted by carboxy or tetrazolyl, Hal1 is halogen, q is an integer from 0 to 4, R3 is formyl, carboxy or tetrazolyl, Y is phenyl substituted by a dioxol radical and optionally by a halogen atom, or by an alkyl or alkoxy radical, and all possible isomeric, i.e. racemic, enantiomeric and diastereoisomeric forms thereof, as well as addition salts of said compounds of formula (I), are disclosed.
(FR) L'invention concerne les nouveaux produits de formule (I), dans laquelle: R1 représente alkyle, A représente un atome de soufre ou d'oxygène, R2 représente carboxy, tétrazolyle ou alkyle, alcoxy, alkylthio substitués par un carboxy ou un tétrazolyle, Hal1 est halogène, q représente un entier de 0 à 4, R3 est formyle, carboxy ou tétrazolyle, Y représente phényle substitué par un radical dioxol et éventuellement par un atome d'halogène, ou par un radical alkyle ou alcoxy ainsi que toutes les formes isomères possibles, racémiques, énantiomères et diastéréoisomères, ainsi que les sels d'addition desdits produits de formule (I).
Designated States: AU, BR, CA, CN, CZ, HU, IL, JP, KR, MX, NO, NZ, PL, RU, SI, SK, TR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
ES2236755EP0863896US5986103JP2000500128 AR03092DE000069634340
GB2307323AU1996075758FR2740773