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1. (WO1997017332) 1-ARYLSULPHONYL, ARYL(THIO)CARBONYL PYRIDAZINO DERIVATIVES AND METHODS OF PREPARATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017332 International Application No.: PCT/US1996/016227
Publication Date: 15.05.1997 International Filing Date: 10.10.1996
Chapter 2 Demand Filed: 30.05.1997
IPC:
C07D 237/26 (2006.01) ,C07D 237/36 (2006.01) ,C07D 491/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
26
condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
26
condensed with carbocyclic rings or ring systems
36
Benzo-cinnolines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
ORTHO PHARMACEUTICAL CORPORATION [US/US]; P.O. Box 300 Route U.S. #202 Raritan, NJ 08869-0602, US
Inventors:
COMBS, Donald, W.; US
Agent:
CIAMPORCERO, Audley, A., Jr. ; Johnson & Johnson One Johnson & Johnson Plaza New Brunswick, NJ 08933, US
Priority Data:
60/007,90006.11.1995US
Title (EN) 1-ARYLSULPHONYL, ARYL(THIO)CARBONYL PYRIDAZINO DERIVATIVES AND METHODS OF PREPARATION
(FR) DERIVES DE PYRIDAZINE D'ARYLSULPHONYL-1 ET D'ARYL(THIO)CARBONYLE ET LEURS PROCEDES DE PREPARATION
Abstract:
(EN) 1-Arylsulphonyl, arylcarbonyl and aryl(thio)carbonyl pyridazino derivatives and processes for making said derivatives are described. The novel derivatives are non-steroidal heterocyclic compounds which act as selective progestins and/or antiprogestins having a high $i(in vitro) affinity for either the uterine, breast or bone progestin receptor. As such, the non-steroidal heterocyclic derivatives are useful in contraception, menopause, osteoporosis or endometriosis.
(FR) L'invention porte sur des dérivés de pyridazine d'arylsulphonyl-1, d'arylcarbonyle et d'arylthiocarbonyle et sur leurs procédés de préparation. Ces dérivés de type nouveau sont des composés hétérocycliques non stéroïdiens agissant en tant que progestérones sélectives et/ou antiprogestérones ayant une affinité $i(in vitro) élevée par le récepteur des progestérones soit de l'utérus, soit du sein, soit des os. En tant que tels, ces dérivés hétérocycliques non stéroïdiens sont utiles dans le cadre de la contraception, de la ménopause, de l'ostéoporose ou de l'endométriose.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1998-1380NO19982030SG53640RU02175969JP2000501073 CN1207091
CA2236896KR1019990067340NZ319979AU1996072637