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1. (WO1997017330) PROCESS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017330 International Application No.: PCT/US1996/018082
Publication Date: 15.05.1997 International Filing Date: 08.11.1996
Chapter 2 Demand Filed: 06.06.1997
IPC:
C07D 311/16 (2006.01) ,C07D 317/60 (2006.01) ,C07D 407/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
04
Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
06
with oxygen or sulfur atoms directly attached in position 2
08
not hydrogenated in the hetero ring
16
substituted in position 7
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
44
ortho- or peri-condensed with carbocyclic rings or ring systems
46
condensed with one six-membered ring
48
Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
50
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
60
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
407
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
SMITHKLINE BEECHAM CORPORATION [US/US]; Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US (AllExceptUS)
WOOD, Jeffery, L. [US/US]; US (UsOnly)
McGUIRE, Michael, Anthony [US/US]; US (UsOnly)
MILLS, Robert, John [GB/US]; US (UsOnly)
PRIDGEN, Lendon, Norwood [US/US]; US (UsOnly)
YU, Marvin, Sungwhan [US/US]; US (UsOnly)
SU, Qiaogong [CN/US]; US (UsOnly)
Inventors:
WOOD, Jeffery, L.; US
McGUIRE, Michael, Anthony; US
MILLS, Robert, John; US
PRIDGEN, Lendon, Norwood; US
YU, Marvin, Sungwhan; US
SU, Qiaogong; US
Agent:
DUSTMAN, Wayne, J. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
60/006,33008.11.1995US
Title (EN) PROCESS
(FR) PROCEDE
Abstract:
(EN) Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[$i(b)]pyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S,2R,3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S,2R,3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
(FR) Procédé perfectionné pour la préparation de dérivés de cyclopentane aromatiques à anneaux condensés. De préférence, les composés préparés selon ce procédé sont les carboxylates d'indane et les dérivés de cyclopentano[$i(b)]pyridine. Plus préférablement, les composés préparés selon ce procédé sont l'acide (+)(1S,2R,3S)-3-[2-(2-hydroxyéth-1-yloxy)-4-méthoxyphényl]-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels pharmaceutiquement acceptables, et l'acide (+)(1S,2R,3S)-3-(2-carboxyméthoxy-4-méthoxyphenyl)-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels pharmaceutiquement acceptables. On a également prévu de nouveaux intermédiaires utilisables dans la préparation de ces composés.
Designated States: AL, AM, AU, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KG, KP, KR, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0876352US6114549US6441173JP2000500142 CA2236929AU1997011187