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1. (WO1997017316) 4-PHENYL-4-OXO-2-BUTENOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017316 International Application No.: PCT/EP1996/004517
Publication Date: 15.05.1997 International Filing Date: 16.10.1996
Chapter 2 Demand Filed: 10.05.1997
IPC:
C07C 59/88 (2006.01) ,C07C 69/738 (2006.01) ,C07C 205/56 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
76
containing keto groups
88
containing halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
66
Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73
of unsaturated acids
738
Esters of keto-carboxylic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
205
Compounds containing nitro groups bound to a carbon skeleton
49
the carbon skeleton being further substituted by carboxyl groups
56
having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
Applicants:
PHARMACIA & UPJOHN S.P.A. [IT/IT]; Via Robert Koch, 1.2 I-20152 Milan, IT (AllExceptUS)
GIORDANI, Antonio [IT/IT]; IT (UsOnly)
PEVARELLO, Paolo [IT/IT]; IT (UsOnly)
SPECIALE, Carmela [IT/IT]; IT (UsOnly)
VARASI, Mario [IT/IT]; IT (UsOnly)
Inventors:
GIORDANI, Antonio; IT
PEVARELLO, Paolo; IT
SPECIALE, Carmela; IT
VARASI, Mario; IT
Priority Data:
9522617.103.11.1995GB
Title (EN) 4-PHENYL-4-OXO-2-BUTENOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY
(FR) DERIVES DE L'ACIDE 4-PHENYL-4-OXO-2-BUTENOIQUE POSSEDANT UNE ACTIVITE INHIBITRICE DE LA KYNURENINE-3-HYDROXYLASE
Abstract:
(EN) 4-Phenyl-4-oxo-butenoic acid derivatives for use in the treatment of the human or animal body by therapy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such an enzyme is needed. The present invention further comprises a selected class of the above mentioned 4-phenyl-4-oxo-butenoic acid derivatives, their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them.
(FR) On décrit des dérivés de l'acide 4-phényl-4-oxo-buténoïque utiles en thérapeutique dans le traitement du corps humain ou animal, et notamment en tant qu'inhibiteurs de la kynurénine-3-hydroxylase dans la prévention et/ou le traitement de maladies neurodégénératives dans lesquelles il est nécessaire d'inhiber une telle enzyme. La présente invention comprend en outre une classe sélectionnée de dérivés de l'acide 4-phényl-4-oxo-buténoïque ci-dessus mentionnés, leurs sels pharmaceutiquement acceptables, un procédé de préparation de ces dérivés, ainsi que des compositions pharmaceutiques contenant ceux-ci.
Designated States: AL, AU, BB, BG, BR, BY, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KP, KR, KZ, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0858442US6048896JP2000511872 AU1996072950