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1. (WO1997017085) A METHOD FOR INHIBITING ATTACHMENT OF H. INFLUENZAE TO HUMAN CELLS USING PHOSPHORYLATED RECOMBINANT HUMAN BETA-CASEIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017085 International Application No.: PCT/US1996/017860
Publication Date: 15.05.1997 International Filing Date: 06.11.1996
Chapter 2 Demand Filed: 03.06.1997
IPC:
A23L 1/305 (2006.01) ,A61K 38/00 (2006.01) ,C07K 14/47 (2006.01)
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1
Foods or foodstuffs; Their preparation or treatment
29
Modifying nutritive qualities of foods; Dietetic products
30
containing additives
305
Amino acids, peptides or proteins 
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
Applicants:
ABBOTT LABORATORIES [US/US]; CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Inventors:
MUKERJI, Pradip; US
THURMOND, Jennifer, M.; US
HANSSON, Lennart; SE
BAXTER, Jeffrey, H.; US
HARDS, Robert, G.; US
LEONARD, Amanda, Eun-Yeong; US
ANDERSON, Steven, N.; US
HARVEY, Linda, A.; US
Agent:
BECKER, Cheryl, L. ; Abbott Laboratories Chad 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Priority Data:
08/552,52906.11.1995US
Title (EN) A METHOD FOR INHIBITING ATTACHMENT OF H. INFLUENZAE TO HUMAN CELLS USING PHOSPHORYLATED RECOMBINANT HUMAN BETA-CASEIN
(FR) PROCEDE PERMETTANT D'INHIBER LA FIXATION DE H. INFLUENZAE SUR DES CELLULES HUMAINES A L'AIDE DE BETA-CASEINE HUMAINE PHOSPHORYLEE DE RECOMBINAISON
Abstract:
(EN) A method is provided for inhibiting the attachment of $i(H. influenzae) to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human $g(b)-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human $g(b)-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human $g(b)-casein may also be administered as a throat spray or used in nose drops or a spray.
(FR) Procédé permettant d'inhiber la fixation de $i(H. influenzae) sur des cellules humaines, telles que les cellules pharyngées, consistant à mettre le bacille en contact avec de la $g(b)-caséine humaine phosphorylée de recombinaison possédant au moins 3 groupes phosphate. Le produit contenant de la $g(b)-caséine humaine phosphorylée de recombinaison peut être un produit nutritionnel entéral liquide tel que du lait maternisé. Ledit produit nutritionnel entéral peut être utilisé pour prévenir et traiter l'otite moyenne chez les nourrissons. La $g(b)-caséine humaine phosphorylée de recombinaison peut également être administrée sous forme d'aérosol pour la gorge ou utilisée dans des gouttes ou des aérosols pour le nez.
Designated States: AU, CA, JP, MX, NZ
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1998/003565EP0862450JP2000500141 CA2234664NZ322369AU1996076104