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1. (WO1997017079) METHOD OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION WITHOUT GRAFT FAILURE OR GRAFT VS. HOST DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017079 International Application No.: PCT/US1996/012426
Publication Date: 15.05.1997 International Filing Date: 29.07.1996
Chapter 2 Demand Filed: 04.06.1997
IPC:
A61K 35/14 (2006.01) ,A61K 35/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
Applicants:
EMORY UNIVERSITY [US/US]; 2009 Ridgewood Drive Atlanta, GA 30322, US (AllExceptUS)
WALLER, Edmund, K. [US/US]; US (UsOnly)
Inventors:
WALLER, Edmund, K.; US
Agent:
PERRYMAN, David, G. ; Needle & Rosenberg Suite 1200 127 Peachtree Street, N.E. Atlanta, GA 30303-1811, US
Priority Data:
08/555,52008.11.1995US
Title (EN) METHOD OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION WITHOUT GRAFT FAILURE OR GRAFT VS. HOST DISEASE
(FR) PROCEDE DE TRANSPLANTATION DE CELLULES SOUCHES HEMATOPOIETIQUES ALLOGENIQUES SANS ECHEC DE GREFFE, ET N'ENTRAINANT PAS DE MALADIE OPPOSANT LE GREFFON A L'HOTE
Abstract:
(EN) The present invention provides a method of transplanting hematopoietic system reconstituting cells from a donor into an allogeneic recipient comprising administering to the recipient, prior to the administration of the hematopoietic system reconstituting cells, an amount of mononuclear cells which are treated so as to render them incapable of proliferating and causing a lethal graft versus host disease effect, but which are effective in enhancing subsequent engraftment of the hematopoietic system reconstituting cells in the recipient; and administering to the recipient an effective amount of hematopoietic system reconstituting cells.
(FR) La présente invention concerne un procédé de transplantation de cellules reconstituant le système hématopoïétique, depuis un donneur chez un récepteur allogénique. Ce procédé consiste à administrer au récepteur, avant l'administration des cellules reconstituant le système hématopoïétique, un certaine quantité de cellules mononucléaires. Ces cellules sont traitées de manière à ce qu'elles ne puissent proliférer ni entraîner d'effet mortel induit par une maladie opposant le greffon à l'hôte, et de manière à ce qu'elles puissent activer efficacement la greffe des cellules reconstituant le système hématopoïétique chez le récepteur. Ce procédé consiste enfin à administrer au récepteur une quantité suffisante pour être efficace de cellules reconstituant le système hématopoïétique.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862443US6213127JP2001509778 CA2237200AU1996066826