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1. (WO1997017063) MICROENCAPSULATED DNA FOR VACCINATION AND GENE THERAPY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017063 International Application No.: PCT/GB1996/002770
Publication Date: 15.05.1997 International Filing Date: 11.11.1996
Chapter 2 Demand Filed: 05.06.1997
IPC:
A61K 9/00 (2006.01) ,A61K 9/16 (2006.01) ,A61K 39/15 (2006.01) ,A61K 39/165 (2006.01) ,A61K 48/00 (2006.01) ,C12N 15/88 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
15
Reoviridae, e.g. calf diarrhea virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
155
Paramyxoviridae, e.g. parainfluenza virus
165
Mumps or measles virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88
using micro-encapsulation, e.g. using liposome vesicle
Applicants:
MICROBIOLOGICAL RESEARCH AUTHORITY [GB/GB]; CAMR (Centre for Applied Microbiology & Research) Porton Down Salisbury Wiltshire SP4 0JG, GB (AllExceptUS)
FARRAR, Graham, Henry [GB/GB]; GB (UsOnly)
JONES, David, Hugh [GB/GB]; GB (UsOnly)
CLEGG, James, Christopher, Stephen [GB/GB]; GB (UsOnly)
Inventors:
FARRAR, Graham, Henry; GB
JONES, David, Hugh; GB
CLEGG, James, Christopher, Stephen; GB
Agent:
SCHLICH, George, William; Mathys & Squire 100 Gray's Inn Road London WCIX 8AL, GB
Priority Data:
9523019.909.11.1995GB
9601929.431.01.1996GB
Title (EN) MICROENCAPSULATED DNA FOR VACCINATION AND GENE THERAPY
(FR) ADN MICROENCAPSULE S'APPLIQUANT DANS DES PROCEDES DE VACCINATION ET DE THERAPIE GENIQUE
Abstract:
(EN) A microparticle contains DNA coding for a polypeptide and oral administration of the microparticle leads to its expression. DNA coding for an immunogen is for stimulating antibody formation in a recipient and DNA coding for a non-immunogenic polypeptide is for gene therapy applications. DNA is incorporated into the microparticle without destruction of its function.
(FR) L'invention se rapporte à une microparticule contenant de l'ADN codant pour un polypeptide et l'administration par voie orale de cette microparticule qui conduit à son expression. L'ADN codant pour un immunogène est destiné à stimuler la formation d'anticorps chez un receveur, et l'ADN codant pour un polypeptide non-immunogène est destiné à être appliqué en thérapie génique. L'ADN est introduit dans la microparticule sans destruction de sa fonction.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)