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1. (WO1997017050) AN IMPROVED METHOD FOR PREPARATION OF SUBSTITUTED TETRAHYDROISOQUINOLINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/017050 International Application No.: PCT/US1996/017926
Publication Date: 15.05.1997 International Filing Date: 08.11.1996
IPC:
C07D 217/26 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
217
Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
22
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
26
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applicants:
MONSANTO COMPANY [US/US]; 800 North Lindbergh Boulevard St. Louis, MO 63167, US
Inventors:
GRIFFIN, Brian; US
JOHNSON, Mark, R.; US
KELLER, Ronald, L.; US
Agent:
FITZPATRICK, Joseph, M.; Fitzpatrick, Cella, Harper & Scinto 277 Park Avenue New York, NY 10172 , US
Priority Data:
08/556,24909.11.1995US
Title (EN) AN IMPROVED METHOD FOR PREPARATION OF SUBSTITUTED TETRAHYDROISOQUINOLINES
(FR) PROCEDE AMELIORE DE PREPARATION DE TETRAHYDROISOQUINOLEINES SUBSTITUEES
Abstract:
(EN) An improved method for the preparation and isolation of optically pure (3S) or (3R)-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid comprises reacting formaldehyde with either D- or L-phenylalanine and hydrobromic acid to prepare the pure hydrobromide salts. The mixture is then cooled to precipitate the optically pure isomer which is filtered and then neutralized with a base to form the free acid and dried.
(FR) Procédé amélioré de préparation et d'isolement d'acide (3S) ou (3R)-1, 2, 3, 4-tétrahydroisoquinoléine-3-carboxylique optiquement pur. Ce procédé consiste à faire réagir du formaldéhyde avec de la phénylalanine D ou L et de l'acide hydrobromique pour obtenir des sels d'hydrobromure pur. Le mélange est ensuite refroidi pour obtenir par précipitation l'isomère optiquement pur qui est filtré puis neutralisé à l'aide d'une base pour former l'acide libre avant d'être séché.
Designated States: AU, CA, JP, KR, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996077244