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1. (WO1997016727) ASSAY BACKGROUND REDUCTION USING GLYCOPROTEINS WITH OXIDIZED CARBOHYDRATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016727 International Application No.: PCT/US1996/016885
Publication Date: 09.05.1997 International Filing Date: 18.10.1996
Chapter 2 Demand Filed: 18.05.1997
IPC:
A61K 38/00 (2006.01) ,C07K 16/28 (2006.01) ,G01N 33/53 (2006.01) ,G01N 33/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
BIOTRANSPLANT, INC. [US/US]; Building 96 13th Street Charlestown Navy Yard Charlestown, MA 02120, US
Inventors:
AWWAD, Michel, G.; US
ABRAHAM, Sonny; US
WHITE-SCHARF, Mary, E.; US
HOPE, James, A.; US
Agent:
HERRON, Charles, J. ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data:
08/548,34001.11.1995US
Title (EN) ASSAY BACKGROUND REDUCTION USING GLYCOPROTEINS WITH OXIDIZED CARBOHYDRATES
(FR) REDUCTION DE L'ACTIVITE DE FOND POUR UN DOSAGE, A L'AIDE DE GLYCOPROTEINES COMPORTANT DES GLUCIDES OXYDES
Abstract:
(EN) Disclosed are a composition and method for determining the levels of specific immune responsiveness to a glycoprotein in an individual being treated therewith by (i) contacting a body fluid sample obtained from the individual prior to glycoprotein treatment with glycoprotein that has been modified to have an oxidized carbohydrate portion; (ii) contacting a body fluid sample obtained from the individual subsequent to glycoprotein treatment with the glycoprotein that has been modified to have an oxidized carbohydrate portion; and (iii) observing the degree of difference in the specific immune response to the oxidized glycoprotein in the pre- and post-treatment samples.
(FR) L'invention concerne une composition et une méthode permettant d'évaluer la réponse immunitaire spécifique d'une glycoprotéine chez un individu traité par ladite composition. Pour cela: (i) on met en contact un échantillon de liquide corporel prélevé chez l'individu avant le traitement par la glycoprotéine modifiée de façon à comporter une partie glucidique oxydée; (ii) on met en contact un échantillon de fluide corporel prélevé chez l'individu après un traitement par la glycoprotéine modifiée de façon à comporter une partie glucidique oxydée; et (iii) on observe la différence entre les échantillons avant et après traitement en ce qui concerne la réponse immunitaire spécifique de la glycoprotéine oxydée.
Designated States: AU, CA, IL, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996074645