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1. (WO1997016717) AUTOMATED PERMEABILITY ANALYSIS SYSTEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016717 International Application No.: PCT/US1996/017339
Publication Date: 09.05.1997 International Filing Date: 01.11.1996
Chapter 2 Demand Filed: 21.05.1997
IPC:
G01N 13/00 (2006.01) ,G01N 33/15 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
13
Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
Applicants:
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, IN 46285, US (AllExceptUS)
KUHFELD, Michael, T. [US/US]; US (UsOnly)
ZYNGER, Jacob [US/US]; US (UsOnly)
HINSHAW, Michael, E. [US/US]; US (UsOnly)
STRATFORD, Robert, E. [US/US]; US (UsOnly)
OSBORNE, Stacy, J. [US/US]; US (UsOnly)
BARLOW, Daryl, T. [US/US]; US (UsOnly)
BELL, Jeff, A. [US/US]; US (UsOnly)
Inventors:
KUHFELD, Michael, T.; US
ZYNGER, Jacob; US
HINSHAW, Michael, E.; US
STRATFORD, Robert, E.; US
OSBORNE, Stacy, J.; US
BARLOW, Daryl, T.; US
BELL, Jeff, A.; US
Agent:
SARUSSI, Steven, J.; McDonnell Boehnen Hulbert & Berghoff, Ltd. 7th floor 300 South Wacker Drive Chicago, IL 60606, US
Priority Data:
60/007,24603.11.1995US
Title (EN) AUTOMATED PERMEABILITY ANALYSIS SYSTEM
(FR) SYSTEME AUTOMATISE POUR UNE ANALYSE DE PERMEABILITE
Abstract:
(EN) The present invention relates to an automated permeability analysis system that increases the capacity, precision, accuracy and reliability of $i(in vitro) drug candidate permeability studies. The inventive permeability analysis system establishes a working environment around which a robotic arm may maneuver to enable a computer to establish and carry out a multitude of simultaneous drug transport experiments, with minimal test operator involvement. The system thereby may be used on a relatively large scale to easily and accurately investigate mechanisms of drug transport across a variety of cell membranes and tissues that act as barriers to drug absorption. In particular, the system may be used with monolayers of cultured epithelial cells.
(FR) Système automatisé pour une analyse de perméabilité, assurant une augmentation de la capacité, de la précision et de la fiabilité des études $i(in vitro) de la perméabilité à un médicament candidat. Ce système crée un milieu de travail dans lequel peut évoluer un bras robotique afin de permettre à un ordinateur de réaliser une multitude d'expériences simultanées concernant le transport d'un médicament en minimisant les interventions de l'opérateur. Par conséquent, ce système peut s'utiliser à une échelle plus ou moins grande dans le but d'analyser facilement et avec précision les mécanismes de transport d'un médicament au travers de plusieurs membranes cellulaires et tissus différents constituant des barrières empêchant l'absorption du médicament. Ledit système peut notamment s'utiliser dans le domaine des cultures en couche monocellulaire de cellules épithéliales.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996075259