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1. (WO1997016568) DETECTION OF HUMAN $g(a)-THALASSEMIA MUTATIONS AND THEIR USE AS PREDICTORS OF BLOOD-RELATED DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016568 International Application No.: PCT/US1996/017565
Publication Date: 09.05.1997 International Filing Date: 30.10.1996
Chapter 2 Demand Filed: 26.05.1997
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
BOWIE, Lemuel, J. [US/US]; US
Inventors:
BOWIE, Lemuel, J.; US
Agent:
NAPOLI, James, J.; Marshall, O'Toole, Gerstein, Murray & Borun Suite 6300 233 South Wacker Drive Chicago, IL 60606, US
Priority Data:
08/550,71531.10.1995US
Title (EN) DETECTION OF HUMAN $g(a)-THALASSEMIA MUTATIONS AND THEIR USE AS PREDICTORS OF BLOOD-RELATED DISORDERS
(FR) DETECTION DES MUTATIONS DE LA THALASSEMIE $g(a) HUMAINE ET LEUR UTILISATION COMME MOYENS DE PREDICTION DES TROUBLES ASSOCIES AU SANG
Abstract:
(EN) The invention is based on the discovery that adults having a genotype comprising a hemoglobin $g(a)-gene deletion are significantly more likely to be hypertensive than adults having a normal ($g(a)$g(a)/$g(a)$g(a)) genotype. The invention provides an improved method for determining a human subject's genotype at the $g(a)-gene loci; a method of screening a human subject for an increased potential of developing hypertension and other blood-related disorders; and provides an apparatus/kit for screening a human subject for a risk of developing hypertension and other blood-related disorders.
(FR) Cette invention se fonde sur la découverte que les adultes ayant un génotype comprenant une délétion du gène $g(a) de l'hémoglobine sont considérablement plus exposés à l'hypertension que les adultes ayant un génotype ($g(a)$g(a)/$g(a)$g(a)) normal. Cette invention propose un procédé amélioré pour déterminer le génotype d'un sujet humain aux emplacements du gène $g(a); un procédé pour déterminer chez un sujet humain un potentiel accru de développement de l'hypertension et d'autres troubles associés au sang; ainsi qu'un appareil/kit pour déterminer chez un sujet humain un risque de développement de l'hypertension et d'autres troubles associés au sang.
Designated States: JP
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0859863JP2000501923