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1. (WO1997016547) ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016547 International Application No.: PCT/US1996/017979
Publication Date: 09.05.1997 International Filing Date: 31.10.1996
Chapter 2 Demand Filed: 02.06.1997
IPC:
A61K 38/00 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street Austin, TX 78701, US
Inventors:
ROTH, Jack, A.; US
ALEMANY, Ramon; US
ZHANG, Wei-Wei; US
MUKHOPADHYAY, Tapas; US
Agent:
HIGHLANDER, Steven, L.; Arnold, White & Durkee P.O. Box 4433 Houston, TX 77210, US
GOWSHALL, Jon, V.; Forrester & Boehmert Franz-Joseph-Str. 38 D-80801 München, DE
Priority Data:
08/550,95931.10.1995US
Title (EN) ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY
(FR) VECTEURS D'EXPRESSION ADENOVIRAUX ANTISENS DU K-ras ET LEUR APPLICATION EN THERAPIE ANTICANCEREUSE
Abstract:
(EN) A variety of genetic constructs are disclosed that will find both $i(in vitro) and $i(in vivo) use in the area of tumor biology and cancer therapy. In particular, adenoviral expression vectors are provided that contain a K-$i(ras) nucleic acid positioned antisense to regulatory control regions. In one embodiment, the adenoviral expression vector is a replication-deficient adenoviral vector lacking the E1 region and containing a K-$i(ras) nucleic acid. Also provided are methods for the inhibition of cancer cell proliferation.
(FR) La présente invention concerne diverses constructions génétiques trouvant une utilisation, tant $i(in vitro) que $i(in vivo), dans le domaine de la biologie tumorale et de la thérapie anticancéreuse. L'invention concerne notamment des vecteurs d'expression adénoviraux contenant un acide nucléique de K-$i(ras) en position antisens par rapport aux régions dirigeant la régulation. Selon une réalisation, le vecteur d'expression adénoviral est un vecteur adénoviral présentant une déficience de réplication auquel manque la région E1 et contenant un acide nucléique de K-$i(ras). L'invention concerne également des procédés permettant d'inhiber la prolifération des cellules cancéreuses.
Designated States: AL, AM, AT, AU, BA, BB, BG, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996076748