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1. (WO1997016542) DIAGNOSTICS AND TREATMENTS OF PERIODONTAL DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016542 International Application No.: PCT/AU1996/000673
Publication Date: 09.05.1997 International Filing Date: 30.10.1996
Chapter 2 Demand Filed: 28.04.1997
IPC:
A61K 38/00 (2006.01) ,C12N 9/52 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
52
derived from bacteria
Applicants:
THE UNIVERSITY OF MELBOURNE [AU/AU]; Grattan Street Parkville, VIC 3052, AU (AllExceptUS)
VICTORIAN DAIRY INDUSTRY AUTHORITY [AU/AU]; 651-653 Victoria Street Abbotsford, VIC 3067, AU (AllExceptUS)
REYNOLDS, Eric, Charles [AU/AU]; AU (UsOnly)
BHOGAL, Peter, Singh [AU/AU]; AU (UsOnly)
SLAKESKI, Nada [AU/AU]; AU (UsOnly)
Inventors:
REYNOLDS, Eric, Charles; AU
BHOGAL, Peter, Singh; AU
SLAKESKI, Nada; AU
Agent:
F.B. RICE & CO.; 28A Montague Street Balmain, NSW 2041, AU
Priority Data:
PN 627530.10.1995AU
Title (EN) DIAGNOSTICS AND TREATMENTS OF PERIODONTAL DISEASE
(FR) DIAGNOSTICS ET TRAITEMENTS DE MALADIES PERIODONTIQUES
Abstract:
(EN) This invention relates to the PrtR-PrtK cell surface protein of $i(Porphyromonas gingivalis) and in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against $i(Porphyromonas gingivalis). The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with $i(P. gingivalis).
(FR) Protéine de surface cellulaire PrtR-PrtK de $i(Porphyromonas gingivalis) et en particulier complexe de protéines associées à des cellules multimères, comprenant les protéines PrtR et PrtK. La présente invention concerne donc un complexe antigénique pratiquement purifié destiné à être utilisé pour susciter une réponse d'anticorps dirigée contre $i(Porphyromonas gingivalis). Ledit complexe comprend au moins un complexe protéique multimère d'endopeptidases thiol spécifiques d'arginine et spécifiques de lysine, chacune contenant au moins un domaine adhésine, ledit complexe ayant un poids moléculaire supérieur à environ 200 kDa. La présente invention concerne également des compositions pharmaceutiques et des agents associés basés sur ledit complexe en vue de la détection, de la prévention et du traitement de maladies périodontiques associées à $i(P. gingivalis).
Designated States: AU, CA, JP, KR, NZ, SG, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG49417EP0858504US6511666US20070189982JP2000510817 US20110213129
CA2235224KR1019990067167NZ320015DK0858504AU1996072673