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1. (WO1997016536) METHOD FOR EX VIVO PROLIFERATION AND DIFFERENTIATION OF ADULT PANCREATIC ISLET CELLS, MEDIA USEFUL THEREFOR AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016536 International Application No.: PCT/US1996/016396
Publication Date: 09.05.1997 International Filing Date: 11.10.1996
Chapter 2 Demand Filed: 30.05.1997
IPC:
C12N 5/071 (2010.01) ,A61K 35/12 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
Applicants:
VIVORX, INC. [US/US]; 2nd floor 3212 Nebraska Avenue Santa Monica, CA 90404, US (AllExceptUS)
SOON-SHIONG, Patrick [US/US]; US (UsOnly)
VARSANYI-NAGY, Maria [HU/US]; US (UsOnly)
FERRERI, Kevin [US/US]; US (UsOnly)
MOLONEY, Molly [US/US]; US (UsOnly)
HEINTZ, Roswitha [US/US]; US (UsOnly)
Inventors:
SOON-SHIONG, Patrick; US
VARSANYI-NAGY, Maria; US
FERRERI, Kevin; US
MOLONEY, Molly; US
HEINTZ, Roswitha; US
Agent:
REITER, Stephen, E.; Gray Cary Ware Freidenrich Suite 1600 4365 Executive Drive San Diego, CA 92121, US
Priority Data:
08/558,59130.10.1995US
Title (EN) METHOD FOR EX VIVO PROLIFERATION AND DIFFERENTIATION OF ADULT PANCREATIC ISLET CELLS, MEDIA USEFUL THEREFOR AND USES THEREOF
(FR) PROCEDE PERMETTANT UNE PROLIFERATION ET UNE DIFFERENTIATION EX VIVO DE CELLULES DES ILOTS PANCREATIQUES ADULTES, MILIEUX UTILES POUR CE PROCEDE ET LEURS UTILISATIONS
Abstract:
(EN) A method for inducing the profileration and differentiation of neonatal and/or adult human or non-human pancreatic islets to produce a product useful, for exmple, as a therapeutic agent for treatment of diabetes has been developed. Invention method involves a series of complex cell culture media containing necessary nutrients and growth factors, a human cytokine (hepatocyte growth factor or scatter factor), a microgravity culture vessel for promoting three dimensional growth, and molecular biology assays for measuring insulin promoter activity. A method for providing a hybrid organoid comprising a combination of donor and recipient cell types is also described.
(FR) L'invention concerne un procédé pour induire la prolifération et la différentiation de cellules d'îlots pancréatiques de foetus et /ou d'individus adultes humains ou non humains, pour obtenir un produit utile, par exemple, comme agent thérapeutique pour le traitement du diabète. Le procédé de l'invention fait appel à une série de milieux complexes pour la culture de cellules contenant les éléments nutritifs et les éléments de croissance nécessaires, une cytokine humaine (facteur de croissance ou facteur de dispersion des hépatocytes), un récipient de culture à microgravité pour favoriser une croissance tridimensionnelle et des dosages de biologie moléculaire pour mesurer l'activité du promoteur de l'insuline. L'invention concerne également un procédé pour réaliser un organoïde hybride comprenant une combinaison de cellules du donneur et de cellules du receveur.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996074439