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1. (WO1997016474) TARGETED MAGNETICALLY LABELED MOLECULAR MARKER SYSTEMS FOR THE NMR IMAGING
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016474 International Application No.: PCT/IB1996/001174
Publication Date: 09.05.1997 International Filing Date: 31.10.1996
IPC:
A61K 49/08 (2006.01) ,A61K 49/18 (2006.01) ,C08G 65/329 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18
characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
65
Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
02
from cyclic ethers by opening of the heterocyclic ring
32
Polymers modified by chemical after-treatment
329
with organic compounds
Applicants:
BRACCO RESEARCH S.A. [CH/CH]; 7, route de Drize CH-1227 Carouge, CH
Inventors:
TOURNIER, Hervé; FR
POCHON, Sibylle; CH
LAMY, Bernard; CH
Agent:
TOMOV-GRISOGONO, Nenad; Bracco Research S.A. 7, route de Drize CH-1227 Carouge, CH
Priority Data:
95810689.001.11.1995EP
Title (EN) TARGETED MAGNETICALLY LABELED MOLECULAR MARKER SYSTEMS FOR THE NMR IMAGING
(FR) SYSTEMES DE MARQUEUR MOLECULAIRE CIBLE, A ETIQUETAGE MAGNETIQUE, POUR IMAGERIE A RESONANCE MAGNETIQUE NUCLEAIRE
Abstract:
(EN) Administrable factors or compositions to be directed to specific sites in the body of human and animal patients which comprise a medically and/or diagnostically effective moiety (I) and, coupled thereto by means of a linker (L), a substance (II) having specific affinity for specific sites in the organism. Linker 'L' has a structure schematized by the formula: Y(W-Z-R)m, m being 1, 2, or 4 wherein the portion YW is an amphiphile, i.e. a segment comprised of a hydrophobic-lipophilic sequence 'Y' and a hydrophilic-lipophobic sequence 'W' connected covalently together, Z is a chemical bond or an intermediate connector sequence and R is a reactive function for effecting coupling with selected substances (II).
(FR) L'invention a trait à des facteurs ou des compositions administrables, à diriger vers des sites spécifiques du corps de patients humains ou animaux, comportant un fragment (I) efficace du point de vue médical et/ou diagnostique ainsi qu'une substance (II), couplée à ce fragment par un segment de liaison (L), dotée d'une affinité spécifique pour des sites spécifiques dans l'organisme. La structure de ce segment de liaison (L) est schématisée par la formule: Y(W-Z-R)m, dans laquelle m vaut 1, 2 ou 4 et où la partie YW représente un amphiphile, c'est-à-dire un segment constitué d'une séquence hydrophobe-lipophile 'Y' et d'une séquence hydrophile-lipophobe 'W' liées ensemble de façon covalente, Z représentant une liaison chimique ou une séquence intermédiaire de connexion et R une focntion réactive servant au couplage de substances sélectionnées (II).
Designated States: JP
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0800545JP4018141 JPH10512617