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1. (WO1997016456) NOVEL NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016456 International Application No.: PCT/KR1996/000189
Publication Date: 09.05.1997 International Filing Date: 01.11.1996
Chapter 2 Demand Filed: 09.05.1997
IPC:
C07D 405/04 (2006.01) ,C07D 473/18 (2006.01) ,C07D 473/40 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
02
with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
18
one oxygen and one nitrogen atom, e.g. guanine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
40
with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Applicants:
CHONG KUN DANG CORP. [KR/KR]; 410, Shindorim-dong Guro-gu Seoul 152-070, KR (AllExceptUS)
KIM, Jung, Woo [KR/KR]; KR (UsOnly)
CHUNG, Koo, Hun [KR/KR]; KR (UsOnly)
AHN, Soon, Kil [KR/KR]; KR (UsOnly)
SON, Hoe, Joo [KR/KR]; KR (UsOnly)
JEONG, Byeong, Seon [KR/KR]; KR (UsOnly)
Inventors:
KIM, Jung, Woo; KR
CHUNG, Koo, Hun; KR
AHN, Soon, Kil; KR
SON, Hoe, Joo; KR
JEONG, Byeong, Seon; KR
Agent:
SUH, Jong, Wan; New-Seoul Building 3rd floor 828-8, Yeoksam-dong Kangnam-ku Seoul 135-080, KR
Priority Data:
1995/3934002.11.1995KR
Title (EN) NOVEL NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THE SAME
(FR) NOUVEAUX DERIVES DE NUCLEOSIDES ET PROCEDE DE PREPARATION CORRESPONDANT
Abstract:
(EN) According to the present invention, provided are novel nucleoside derivatives having anti-viral activity, in particular, anti-HBV (anti-Hepatitis-B Virus) activity, represented by general formula (I), wherein R1 represents hydrogen, phosphate, phosphonate, alkyl or acyl, R2 represents alkoxy or halogen, R3 represents substituted or non-substituted pyrimidine or purine base, and X represents O, S, SO or SO2; pharmaceutically acceptable salts thereof, and processes for preparation thereof. As the compound (I) has two or more asymmetric carbon atoms, all possible stereoisomers and mixtures thereof are included in the scope of the present invention.
(FR) La présente invention se rapporte à de nouveaux dérivés de nucléosides possédant une activité antivirale, et notamment une activité dirigée contre le virus de l'hépatite B (HBV), qui sont représentés par la formule générale (I), ainsi qu'à des sels pharmaceutiquement acceptables de ces dérivés et à des procédés de préparation de tels composés. Dans la formule (I), R1 représente l'hydrogène, un phosphate, un phosphonate, un alkyle ou un acyle, R2 représente un alkoxy ou un halogène, R3 représente une base pyrimidique ou purique, substituée ou non substituée, et X représente O, S, SO ou SO2. Etant donné que le composé représenté par la formule (I) possède au moins deux atomes de carbone asymétriques, l'invention concerne également tous les stéréo-isomères et les mélanges possibles de ce composé.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0882058US6072051JPH11514642 CN1201463CA2235598AU1996073418